Identification of Navβ1 residues involved in the modulation of the sodium channel Nav1.4.

Identification of Navβ1 residues involved in the modulation of the sodium channel Nav1.4.

Voltage-gated sodium channels (VGSCs) are heteromeric protein complexes that initiate action potentials in excitable cells. The voltage-gated sodium channel accessory subunit, Navβ1, allosterically modulates the α subunit pore structure upon binding. To date, the molecular determinants of the interf...

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Bibliographic Details
Main Authors: Angel A Islas, Alfredo Sánchez-Solano, Thomas Scior, Lourdes Millan-PerezPeña, Eduardo M Salinas-Stefanon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24358138/?tool=EBI

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