Molecular Crosstalk Between MYC and HIF in Cancer

Molecular Crosstalk Between MYC and HIF in Cancer

The transcription factor c-MYC (MYC thereafter) is a global regulator of gene expression. It is overexpressed or deregulated in human cancers of diverse origins and plays a key role in the development of cancers. Hypoxia-inducible factors (HIFs), a central regulator for cells to adapt to low cellula...

Full description

Bibliographic Details
Main Authors:	Yanping Li, Xiao-Xin Sun, David Z. Qian, Mu-Shui Dai
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-11-01
Series:	Frontiers in Cell and Developmental Biology
Subjects:	MYC HIF1α HIF2α transcription protein stability metabolism
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2020.590576/full

Similar Items

Dual Targeting Oncoproteins MYC and HIF1α Regresses Tumor Growth of Lung Cancer and Lymphoma
by: Xiaohu Huang, et al.
Published: (2021-02-01)

HIF-1α Modulates Core Metabolism and Virus Replication in Primary Airway Epithelial Cells Infected with Respiratory Syncytial Virus
by: Dorothea R. Morris, et al.
Published: (2020-09-01)

Endothelial cell regulation of systemic haemodynamics and metabolism acts through the HIF transcription factors
by: Simon Lambden, et al.
Published: (2021-06-01)

Specific Inhibition of HIF Activity: Can Peptides Lead the Way?
by: Ilias Mylonis, et al.
Published: (2021-01-01)

Upregulation of the Chemokine Receptor CCR7 expression by HIF-1αand HIF-2α in non-small cell lung cancer
by: Yang LI, et al.
Published: (2008-10-01)

Deterioration of alveolar development in mice with both HIF-3α knockout and HIF-2α knockdown
by: Firman Zulkifli Amin, et al.
Published: (2018-07-01)

Regulation of the Hypoxia-Inducible Factor (HIF) by Pro-Inflammatory Cytokines
by: Mykyta I. Malkov, et al.
Published: (2021-09-01)

HIF-1α pathway: role, regulation and intervention for cancer therapy
by: Georgina N. Masoud, et al.
Published: (2015-09-01)

Salidroside and FG-4592 ameliorate high glucose-induced glomerular endothelial cells injury via HIF upregulation
by: Rui-yan Xie, et al.
Published: (2019-10-01)

Relative hypoxia and oxidative stress in spleen lymphocytes of immunized Balb/c mice as indicated by HIF-1α, HIF-2α, Nrf2 expression, and glutathione peroxidase activity
by: Citra Praditi, et al.
Published: (2018-12-01)

Interplay between sirtuins, MYC and hypoxia-inducible factor in cancer-associated metabolic reprogramming
by: Bernadette M. M. Zwaans, et al.
Published: (2014-09-01)

Hypoxia Inducible Factor-1α (HIF-1 α) and its Role in Tumour Progression to Malignancy
by: Gaurav Mrinal Sharma
Published: (2008-07-01)

Role of HIF-1α in Alcohol-Mediated Multiple Organ Dysfunction
by: Niya L. Morris, et al.
Published: (2018-12-01)

AKR1C1 promotes non-small cell lung cancer proliferation via crosstalk between HIF-1α and metabolic reprogramming
by: Chang, L.-L, et al.
Published: (2022)

HIF-1α Deletion in the Endothelium, but Not in the Epithelium, Protects From Radiation-Induced Enteritis
by: Aurore Toullec, et al.
Published: (2018-01-01)

Silencing c-Myc Enhances the Antitumor Activity of Bufalin by Suppressing the HIF-1α/SDF-1/CXCR4 Pathway in Pancreatic Cancer Cells
by: Xia Liu, et al.
Published: (2020-04-01)

miR-135b-5p Suppresses Androgen Receptor-Enhanced Hepatocellular Carcinoma Cell Proliferation via Regulating the HIF-2α/c-Myc/P27 Signals in vitro
by: Bao S, et al.
Published: (2020-10-01)

HIF1α is required for NK cell metabolic adaptation during virus infection
by: Francisco Victorino, et al.
Published: (2021-08-01)

The role of HIF-1α in chemo-/radioresistant tumors
by: Xia Y, et al.
Published: (2018-05-01)

Dysregulated expression of hypoxia-inducible factors augments myofibroblasts differentiation in idiopathic pulmonary fibrosis
by: Arnoldo Aquino-Gálvez, et al.
Published: (2019-06-01)

Different Expressions of HIF-1α and Metabolism in Brain and Major Visceral Organs of Acute Hypoxic Mice
by: Lu Xu, et al.
Published: (2021-06-01)

α-Hederin inhibits the growth of lung cancer A549 cells in vitro and in vivo by decreasing SIRT6 dependent glycolysis
by: Cong Fang, et al.
Published: (2021-01-01)

JNK Contributes to Hif-1α Regulation in Hypoxic Neurons
by: Xanthi Antoniou, et al.
Published: (2009-12-01)

HIF pathway and c-Myc as biomarkers for response to sunitinib in metastatic clear-cell renal cell carcinoma
by: Maroto P, et al.
Published: (2017-09-01)

Insights into Temperature and Hypoxia Tolerance in Cowpea Weevil via HIF-1
by: Qin Liu, et al.
Published: (2021-06-01)

High expression of NDRG3 in osteoarthritis patients
by: Long Chen, et al.
Published: (2021-03-01)

Hif-1α and IGF Expression in Endometrial Hyperplasia
by: Z. V. Chumak, et al.
Published: (2020-11-01)

Role and Regulation of Mechanotransductive HIF-1α Stabilisation in Periodontal Ligament Fibroblasts
by: Christian Kirschneck, et al.
Published: (2020-12-01)

NADPH promotes the rapid growth of the tumor
by: Hao Sheng
Published: (2018-04-01)

Metabolic Roles of Androgen Receptor and Tip60 in Androgen-Dependent Prostate Cancer
by: Kah Ni Tan, et al.
Published: (2020-09-01)

HIF-1α is Overexpressed in Odontogenic Keratocyst Suggesting Activation of HIF-1α and NOTCH1 Signaling Pathways
by: Natacha Malu Miranda da Costa, et al.
Published: (2019-07-01)

Expression of HIF-1α and VEGF in Glioma A172 Cells After Gene Intervention
by: LI Qin, et al.
Published: (2019-06-01)

Implications of HIF-1α in the tumorigenesis and progression of pancreatic cancer
by: Xiao Jin, et al.
Published: (2020-06-01)

Efforts to overcome hypoxia condition in Balb/c mouse macrophages after intraperitoneal SRBC immunization
by: Pungguri Ayu Nega Sarsanti, et al.
Published: (2019-05-01)

Association of hypoxia inducible factor 1 (HIF-1) and paraoxonase enzyme in lung cancer cell lines
by: Nedim Karagenç, et al.
Published: (2015-09-01)

The Linkage between Breast Cancer, Hypoxia, and Adipose Tissue
by: Linda K. Rausch, et al.
Published: (2017-09-01)

Effect of the Hypoxia Inducible Factor on Sorafenib Resistance of Hepatocellular Carcinoma
by: Zhi Zeng, et al.
Published: (2021-07-01)

FUBP1 promotes neuroblastoma proliferation via enhancing glycolysis-a new possible marker of malignancy for neuroblastoma
by: Ping Jiang, et al.
Published: (2019-09-01)

Differential Cytotoxicity Mechanisms of Copper Complexed with Disulfiram in Oral Cancer Cells
by: Ssu-Yu Chen, et al.
Published: (2021-04-01)

Yes-associated protein (YAP) binds to HIF-1α and sustains HIF-1α protein stability to promote hepatocellular carcinoma cell glycolysis under hypoxic stress
by: Xiaodong Zhang, et al.
Published: (2018-09-01)