Association between hyperacuity defects and retinal microstructure in polypoidal choroidal vasculopathy

• Main Authors: Moosang Kim, Seung-Young Yu, Hyung-Woo Kwak
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2014-01-01
• Series: Indian Journal of Ophthalmology
• Subjects: Color Doppler imaging; hypertensive retinopathy; resistive index; Conjunctival graft; primary pterygium; recurrent pterygium; Intraocular pressure; singleton pregnancy; the number of fetuses; twin pregnancy; Accommodation; agreement; amplitude of accommodation; push-up method; Intraocular lens; non-sclera flap; transscleral pars plana suture fixation; Axial length; formulas; lens; power; short eyes; Acquired esotropia; favourable outcome; stereopsis; Diabetic retinopathy; enzyme-linked immunosorbent assay; immunology; interleukin-1β; interleukin-10; proliferative; Polypoidal choroidal vasculopathy; preferential hyperacuity perimetry; spectral-domain optical coherence tomography
• Online Access: http://www.ijo.in/article.asp?issn=0301-4738;year=2014;volume=62;issue=6;spage=702;epage=706;aulast=Kim

Purpose: To improve our understanding of hyperacuity defects measured with preferential hyperacuity perimetry (PHP) by correlating PHP findings with the retinal microstructural changes visible on spectral-domain optical coherence tomography (OCT) in patients with polypoidal choroidal vasculopathy (PCV). Materials and Methods: Twenty-eight eyes of 28 patients with PCV were retrospectively reviewed. All patients underwent a complete ophthalmologic examination, including best-corrected visual acuity (logMAR) testing, PHP, and OCT. The functional ′PHP test score′ and ′total volume of hyperacuity defect zone′ were also analyzed. Results: Patients were classified based on the hyperacuity defect by PHP, as follows: Hyperacuity defect (n = 17 eyes) group and hyperacuity intact (n = 11 eyes) group. The mean best-corrected visual acuity in the hyperacuity intact group (0.46 ± 0.39) was better than that in the hyperacuity defect group (0.82 ± 0.37) (P = 0.014). The presence of serous retinal detachment and retinal pigment epithelial detachment did not differ significantly between groups (P = 0.120 and P = 0.689, respectively). A disrupted photoreceptor layer was more common in the hyperacuity defect group compared with the hyperacuity intact group (P = 0.0001). Among 17 eyes with a hyperacuity defect, 9 eyes showing intra-retinal pathology (intra-retinal cyst or hard exudates) and had a significantly higher PHP test score and larger total volume of the hyperacuity defect zone than 8 eyes without intra-retinal pathology (P = 0.006 and P = 0.021, respectively). Conclusion: A hyperacuity defect in PCV was associated with photoreceptor disarrangement. Furthermore, PCV lesions on the inner retina that invaded the photoreceptor layer were associated with a more severe hyperacuity defect.