Formulation and Efficacy of Catalase-Loaded Nanoparticles for the Treatment of Neonatal Hypoxic-Ischemic Encephalopathy

Formulation and Efficacy of Catalase-Loaded Nanoparticles for the Treatment of Neonatal Hypoxic-Ischemic Encephalopathy

Neonatal hypoxic-ischemic encephalopathy is the leading cause of permanent brain injury in term newborns and currently has no cure. Catalase, an antioxidant enzyme, is a promising therapeutic due to its ability to scavenge toxic reactive oxygen species and improve tissue oxygen status. However, upon...

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Bibliographic Details
Main Authors: Andrea Joseph, Chris W. Nyambura, Danielle Bondurant, Kylie Corry, Denise Beebout, Thomas R. Wood, Jim Pfaendtner, Elizabeth Nance
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Pharmaceutics
Subjects:
hypoxia-ischemia
hydrophobic-ion pairing
catalase
nanomedicine
neonatal
molecular dynamics
Online Access:https://www.mdpi.com/1999-4923/13/8/1131

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