Hepatoprotective effect of biherbal ethanolic extract against paracetamol-induced hepatic damage in albino rats

• Main Authors: D Anantha Krishna Chaitanya, Challa Siva Reddy, A Manohar Reddy
• Format: Article
• Language: English
• Published: Elsevier 2012-01-01
• Series: Journal of Ayurveda and Integrative Medicine
• Subjects: Biherbal ethanolic extract; heptoprotective; paracetamol; serum glutamate oxaloacetate transaminase
• Online Access: http://www.jaim.in/article.asp?issn=0975-9476;year=2012;volume=3;issue=4;spage=198;epage=203;aulast=Chaitanya

Aim : The combined hepatoprotective effect of Bi-herbal ethanolic extract (BHEE) was evaluated against paracetamol induced hepatic damage in albino rats. Materials and Methods: Liver function tests and biochemical parameters were estimated using standard kits. Livers were quickly removed and fixed in 10% formalin and subjected to histopathological studies. Results : Ethanolic extract from the leaves of Aerva lanata and leaves of Achyranthes aspera at a dose level of 200 mg/kg, 400mg/kg body weight was administered orally once for 3 days. Substantially elevated serum marker enzymes such as SGOT, SGPT, ALP, due to paracetamol treatment were restored towards normal. Biochemical parameters like total protein, total bilirubin, total cholesterol, triglycerides, and urea were also restored towards normal levels. In addition, BHEE significantly decreased the liver weight of paracetamol intoxicated rats. Silymarin at a dose level of 25 mg/kg used as a standard reference also exhibited significant hepatoprotective activity against paracetamol induced hepatotoxicity. Conclusion : The results of this study strongly indicate that BHEE has got a potent hepatoprotective action against paracetamol induced hepatic damage in rats.