A novel age-informed approach for genetic association analysis in Alzheimer’s disease

A novel age-informed approach for genetic association analysis in Alzheimer’s disease

Abstract Background Many Alzheimer’s disease (AD) genetic association studies disregard age or incorrectly account for it, hampering variant discovery. Methods Using simulated data, we compared the statistical power of several models: logistic regression on AD diagnosis adjusted and not adjusted for...

Full description

Bibliographic Details
Main Authors: Yann Le Guen, Michael E. Belloy, Valerio Napolioni, Sarah J. Eger, Gabriel Kennedy, Ran Tao, Zihuai He, Michael D. Greicius, for the Alzheimer’s Disease Neuroimaging Initiative
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Genetics
Whole-exome sequencing
Exome-wide association
Age adjustment
Cox regression
Online Access:https://doi.org/10.1186/s13195-021-00808-5

Internet

https://doi.org/10.1186/s13195-021-00808-5

Similar Items