Spatial quality control bypasses cell-based limitations on proteostasis to promote prion curing

Spatial quality control bypasses cell-based limitations on proteostasis to promote prion curing

The proteostasis network has evolved to support protein folding under normal conditions and to expand this capacity in response to proteotoxic stresses. Nevertheless, many pathogenic states are associated with protein misfolding, revealing in vivo limitations on quality control mechanisms. One contr...

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Bibliographic Details
Main Authors: Courtney L Klaips, Megan L Hochstrasser, Christine R Langlois, Tricia R Serio
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-12-01
Series:eLife
Subjects:
chaperone
protein misfolding
amyloid
prion
Online Access:https://elifesciences.org/articles/04288

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