Regulatory networks and complex interactions between the insulin and angiotensin II signalling systems: models and implications for hypertension and diabetes.

Regulatory networks and complex interactions between the insulin and angiotensin II signalling systems: models and implications for hypertension and diabetes.

The cross-talk between insulin and angiotensin II signalling pathways plays a significant role in the co-occurrence of diabetes and hypertension. We developed a mathematical model of the system of interactions among the biomolecules that are involved in the cross-talk between the insulin and angiote...

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Main Authors: Deniz Cizmeci, Yaman Arkun
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24400038/pdf/?tool=EBI
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spelling doaj-a7c0458bb7934aaabb0e9b46c669f4812021-03-04T12:35:56ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01812e8364010.1371/journal.pone.0083640Regulatory networks and complex interactions between the insulin and angiotensin II signalling systems: models and implications for hypertension and diabetes.Deniz CizmeciYaman ArkunThe cross-talk between insulin and angiotensin II signalling pathways plays a significant role in the co-occurrence of diabetes and hypertension. We developed a mathematical model of the system of interactions among the biomolecules that are involved in the cross-talk between the insulin and angiotensin II signalling pathways. We have identified several feedback structures that regulate the dynamic behavior of the individual signalling pathways and their interactions. Different scenarios are simulated and dominant steady-state, dynamic and stability characteristics are revealed. The proposed mechanistic model describes how angiotensin II inhibits the actions of insulin and impairs the insulin-mediated vasodilation. The model also predicts that poor glycaemic control induced by diabetes contributes to hypertension by activating the renin angiotensin aystem.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24400038/pdf/?tool=EBI
collection DOAJ
language English
format Article
sources DOAJ
author Deniz Cizmeci
Yaman Arkun
spellingShingle Deniz Cizmeci
Yaman Arkun
Regulatory networks and complex interactions between the insulin and angiotensin II signalling systems: models and implications for hypertension and diabetes.
PLoS ONE
author_facet Deniz Cizmeci
Yaman Arkun
author_sort Deniz Cizmeci
title Regulatory networks and complex interactions between the insulin and angiotensin II signalling systems: models and implications for hypertension and diabetes.
title_short Regulatory networks and complex interactions between the insulin and angiotensin II signalling systems: models and implications for hypertension and diabetes.
title_full Regulatory networks and complex interactions between the insulin and angiotensin II signalling systems: models and implications for hypertension and diabetes.
title_fullStr Regulatory networks and complex interactions between the insulin and angiotensin II signalling systems: models and implications for hypertension and diabetes.
title_full_unstemmed Regulatory networks and complex interactions between the insulin and angiotensin II signalling systems: models and implications for hypertension and diabetes.
title_sort regulatory networks and complex interactions between the insulin and angiotensin ii signalling systems: models and implications for hypertension and diabetes.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2013-01-01
description The cross-talk between insulin and angiotensin II signalling pathways plays a significant role in the co-occurrence of diabetes and hypertension. We developed a mathematical model of the system of interactions among the biomolecules that are involved in the cross-talk between the insulin and angiotensin II signalling pathways. We have identified several feedback structures that regulate the dynamic behavior of the individual signalling pathways and their interactions. Different scenarios are simulated and dominant steady-state, dynamic and stability characteristics are revealed. The proposed mechanistic model describes how angiotensin II inhibits the actions of insulin and impairs the insulin-mediated vasodilation. The model also predicts that poor glycaemic control induced by diabetes contributes to hypertension by activating the renin angiotensin aystem.
url https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24400038/pdf/?tool=EBI
work_keys_str_mv AT denizcizmeci regulatorynetworksandcomplexinteractionsbetweentheinsulinandangiotensiniisignallingsystemsmodelsandimplicationsforhypertensionanddiabetes
AT yamanarkun regulatorynetworksandcomplexinteractionsbetweentheinsulinandangiotensiniisignallingsystemsmodelsandimplicationsforhypertensionanddiabetes
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