CSF1R Inhibition Reduces Microglia Proliferation, Promotes Tissue Preservation and Improves Motor Recovery After Spinal Cord Injury

CSF1R Inhibition Reduces Microglia Proliferation, Promotes Tissue Preservation and Improves Motor Recovery After Spinal Cord Injury

Spinal cord injury (SCI) induces a pronounced neuroinflammation driven by activation and proliferation of resident microglia as well as infiltrating peripheral monocyte-derived macrophages. Depending on the time post-lesion, positive and detrimental influences of microglia/macrophages on axonal rege...

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Bibliographic Details
Main Authors: Yannick Nicolas Gerber, Guillaume Patrick Saint-Martin, Claire Mathilde Bringuier, Sylvain Bartolami, Christophe Goze-Bac, Harun Najib Noristani, Florence Evelyne Perrin
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
spinal cord injury
reduced microglia proliferation
colony stimulating factor 1 receptor
GW2580
motor recovery
reduced gliosis
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00368/full

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