MicroRNA-20b Promotes Cardiac Hypertrophy by the Inhibition of Mitofusin 2-Mediated Inter-organelle Ca2+ Cross-Talk

MicroRNA-20b Promotes Cardiac Hypertrophy by the Inhibition of Mitofusin 2-Mediated Inter-organelle Ca2+ Cross-Talk

MicroRNA (miRNA) and mitofusin-2 (Mfn2) are important in the development of cardiac hypertrophy, but the target relationship and mechanism associated with Ca2+ handling between SR and mitochondria under hypertrophic condition is not established. Mfn2 expression, Mfn2-mediated interorganelle Ca2+ cro...

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Bibliographic Details
Main Authors: Yue Qiu, Rongchao Cheng, Chaoqi Liang, Yuan Yao, Wenhao Zhang, Jie Zhang, Mingyu Zhang, Baiyan Li, Chaoqian Xu, Rong Zhang
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:Molecular Therapy: Nucleic Acids
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253120300524

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http://www.sciencedirect.com/science/article/pii/S2162253120300524

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