Simple PCR assays improve the sensitivity of HIV-1 subtype B drug resistance testing and allow linking of resistance mutations.

Simple PCR assays improve the sensitivity of HIV-1 subtype B drug resistance testing and allow linking of resistance mutations.

BACKGROUND: The success of antiretroviral therapy is known to be compromised by drug-resistant HIV-1 at frequencies detectable by conventional bulk sequencing. Currently, there is a need to assess the clinical consequences of low-frequency drug resistant variants occurring below the detection limit...

Full description

Bibliographic Details
Main Authors: Jeffrey A Johnson, Jin-Fen Li, Xierong Wei, Jonathan Lipscomb, Diane Bennett, Ashley Brant, Mian-Er Cong, Thomas Spira, Robert W Shafer, Walid Heneine
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC1919426?pdf=render

Similar Items

Similar Items