SPDEF inhibits prostate carcinogenesis by disrupting a positive feedback loop in regulation of the Foxm1 oncogene.

SPDEF inhibits prostate carcinogenesis by disrupting a positive feedback loop in regulation of the Foxm1 oncogene.

SAM-pointed domain-containing ETS transcription factor (SPDEF) is expressed in normal prostate epithelium. While its expression changes during prostate carcinogenesis (PCa), the role of SPDEF in prostate cancer remains controversial due to the lack of genetic mouse models. In present study, we gener...

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Bibliographic Details
Main Authors: Xin-Hua Cheng, Markaisa Black, Vladimir Ustiyan, Tien Le, Logan Fulford, Anusha Sridharan, Mario Medvedovic, Vladimir V Kalinichenko, Jeffrey A Whitsett, Tanya V Kalin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-09-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4177813?pdf=render

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