Visible-Light-Induced C–C Coupling Reaction to Synthesize Bipyridine From 3-Cyano-1,4-Dihydropyridines
A concise and efficient photocatalytic C–C coupling of 1-benzyl-3-cyano-1, 4-dihydropyridine for synthesis of 1,1′-dibenzyl-3, 3′-dicyano-1,1′,4,4′-tetrahydro-4, 4′-bipyridine is described. The reporter system provides a novel technique that facilitates synthesis of C–C coupling derivatives without...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-01-01
|
| Series: | Frontiers in Chemistry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fchem.2019.00940/full |
| Summary: | A concise and efficient photocatalytic C–C coupling of 1-benzyl-3-cyano-1, 4-dihydropyridine for synthesis of 1,1′-dibenzyl-3, 3′-dicyano-1,1′,4,4′-tetrahydro-4, 4′-bipyridine is described. The reporter system provides a novel technique that facilitates synthesis of C–C coupling derivatives without addition of transition metals and oxidants or other additives. A plausible synthetic pathway is proposed, and the coupling product was characterized via nuclear magnetic resonance spectroscopy (1H and 13C NMR), high-resolution electrospray ionization mass spectrometry (ESI-HRMS) and X-ray analyses. |
|---|---|
| ISSN: | 2296-2646 |