Structural basis for ligand recognition of the neuropeptide Y Y2 receptor

Structural basis for ligand recognition of the neuropeptide Y Y2 receptor

The human neuropeptide Y receptor Y2 (Y2R) is a drug target for the treatment of obesity and anxiety. Crystal structure of Y2R bound to a selective antagonist and accompanying mutagenesis provide insights into ligand recognition and subtype specificity of NPY receptors.

Bibliographic Details
Main Authors: Tingting Tang, Christin Hartig, Qiuru Chen, Wenli Zhao, Anette Kaiser, Xuefeng Zhang, Hui Zhang, Honge Qu, Cuiying Yi, Limin Ma, Shuo Han, Qiang Zhao, Annette G. Beck-Sickinger, Beili Wu
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21030-9

Internet

https://doi.org/10.1038/s41467-021-21030-9

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