Design and Synthesis of New N-(5-Trifluoromethyl)-1H-1,2,4-triazol-3-yl Benzenesulfonamides as Possible Antimalarial Prototypes

Design and Synthesis of New N-(5-Trifluoromethyl)-1H-1,2,4-triazol-3-yl Benzenesulfonamides as Possible Antimalarial Prototypes

A rational approach was used to synthesize a new set of 15 1H-1,2,4-triazol-3-yl benzenesulfonamide derivatives with the aim of developing new antimalarial lead compounds. These derivatives were prepared in yields between 50% and 62%, and their structures were elucidated using IR, 1H-, 13C-, 19F-NMR...

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Bibliographic Details
Main Authors: Nubia Boechat, Osvaldo A. Santos-Filho, Isabor C. Silva, Luiz C.S. Pinheiro
Format: Article
Language:English
Published: MDPI AG 2011-09-01
Series:Molecules
Subjects:
malaria
sulfonamide
trifluoromethyl
dihydropteroate synthase
DHPS
Online Access:http://www.mdpi.com/1420-3049/16/9/8083/
Description
Summary:A rational approach was used to synthesize a new set of 15 1H-1,2,4-triazol-3-yl benzenesulfonamide derivatives with the aim of developing new antimalarial lead compounds. These derivatives were prepared in yields between 50% and 62%, and their structures were elucidated using IR, 1H-, 13C-, 19F-NMR, MS and elemental analysis. A docking study based on sulfonamides previously used against malaria identified trifluoromethyl-substituted derivatives to be the best lead compounds for new antimalarial drug development.
ISSN:1420-3049

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