Transcriptional profiling of Mycobacterium tuberculosis replicating in the human type II alveolar epithelial cell line, A549

Transcriptional profiling of Mycobacterium tuberculosis replicating in the human type II alveolar epithelial cell line, A549

Alveolar epithelial cells outnumber alveolar macrophages by ~500 fold and increasing evidence suggests that Mycobacterium tuberculosis may replicate dramatically in these cells during the initial weeks of infecting the lung (Wolf et al., 2008 [1]; Ryndak et al., 2015 [2]). Here, we report in experim...

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Main Authors: Michelle B. Ryndak, Krishna K. Singh, Zhengyu Peng, Suman Laal
Format: Article
Language:English
Published: Elsevier 2015-09-01
Series:Genomics Data
Online Access:http://www.sciencedirect.com/science/article/pii/S2213596015000896
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spelling doaj-a7b04f6f1e0d4b2e9d62e11c6a341d162020-11-24T21:51:50ZengElsevierGenomics Data2213-59602015-09-015C11211410.1016/j.gdata.2015.05.026Transcriptional profiling of Mycobacterium tuberculosis replicating in the human type II alveolar epithelial cell line, A549Michelle B. Ryndak0Krishna K. Singh1Zhengyu Peng2Suman Laal3Department of Pathology, New York University Langone Medical Center, New York, NY, USADepartment of Pathology, New York University Langone Medical Center, New York, NY, USAInstitutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, ChinaDepartment of Pathology, New York University Langone Medical Center, New York, NY, USAAlveolar epithelial cells outnumber alveolar macrophages by ~500 fold and increasing evidence suggests that Mycobacterium tuberculosis may replicate dramatically in these cells during the initial weeks of infecting the lung (Wolf et al., 2008 [1]; Ryndak et al., 2015 [2]). Here, we report in experimental detail the transcriptional profiling of M. tuberculosis replicating at 72 h post-infection in the human type II alveolar epithelial cell line, A549, as compared to M. tuberculosis growing logarithmically in laboratory broth culture (Ryndak et al., 2015 [2]). All resulting transcriptional profiling data was deposited to the Gene Expression Omnibus (GEO) database under the accession number GSE58466.http://www.sciencedirect.com/science/article/pii/S2213596015000896
collection DOAJ
language English
format Article
sources DOAJ
author Michelle B. Ryndak
Krishna K. Singh
Zhengyu Peng
Suman Laal
spellingShingle Michelle B. Ryndak
Krishna K. Singh
Zhengyu Peng
Suman Laal
Transcriptional profiling of Mycobacterium tuberculosis replicating in the human type II alveolar epithelial cell line, A549
Genomics Data
author_facet Michelle B. Ryndak
Krishna K. Singh
Zhengyu Peng
Suman Laal
author_sort Michelle B. Ryndak
title Transcriptional profiling of Mycobacterium tuberculosis replicating in the human type II alveolar epithelial cell line, A549
title_short Transcriptional profiling of Mycobacterium tuberculosis replicating in the human type II alveolar epithelial cell line, A549
title_full Transcriptional profiling of Mycobacterium tuberculosis replicating in the human type II alveolar epithelial cell line, A549
title_fullStr Transcriptional profiling of Mycobacterium tuberculosis replicating in the human type II alveolar epithelial cell line, A549
title_full_unstemmed Transcriptional profiling of Mycobacterium tuberculosis replicating in the human type II alveolar epithelial cell line, A549
title_sort transcriptional profiling of mycobacterium tuberculosis replicating in the human type ii alveolar epithelial cell line, a549
publisher Elsevier
series Genomics Data
issn 2213-5960
publishDate 2015-09-01
description Alveolar epithelial cells outnumber alveolar macrophages by ~500 fold and increasing evidence suggests that Mycobacterium tuberculosis may replicate dramatically in these cells during the initial weeks of infecting the lung (Wolf et al., 2008 [1]; Ryndak et al., 2015 [2]). Here, we report in experimental detail the transcriptional profiling of M. tuberculosis replicating at 72 h post-infection in the human type II alveolar epithelial cell line, A549, as compared to M. tuberculosis growing logarithmically in laboratory broth culture (Ryndak et al., 2015 [2]). All resulting transcriptional profiling data was deposited to the Gene Expression Omnibus (GEO) database under the accession number GSE58466.
url http://www.sciencedirect.com/science/article/pii/S2213596015000896
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AT krishnaksingh transcriptionalprofilingofmycobacteriumtuberculosisreplicatinginthehumantypeiialveolarepithelialcelllinea549
AT zhengyupeng transcriptionalprofilingofmycobacteriumtuberculosisreplicatinginthehumantypeiialveolarepithelialcelllinea549
AT sumanlaal transcriptionalprofilingofmycobacteriumtuberculosisreplicatinginthehumantypeiialveolarepithelialcelllinea549
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