The selective orexin receptor 1 antagonist ACT-335827 in a rat model of diet-induced obesity associated with metabolic syndrome

The selective orexin receptor 1 antagonist ACT-335827 in a rat model of diet-induced obesity associated with metabolic syndrome

The orexin system regulates feeding, nutrient metabolism and energy homeostasis. Acute pharmacological blockade of orexin receptor 1 (OXR-1) in rodents induces satiety and reduces normal and palatable food intake. Genetic OXR-1 deletion in mice improves hyperglycemia under high-fat (HF) diet conditi...

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Bibliographic Details
Main Authors: Michel Alexander Steiner, Carla eSciarretta, Anne ePasquali, Francois eJenck
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-12-01
Series:Frontiers in Pharmacology
Subjects:
Lipid Metabolism
metabolic syndrome
diet-induced obesity
food intake
orexin
food preference
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2013.00165/full

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