Humoral Responses Elicited by Adenovirus Displaying Epitopes Are Induced Independently of the Infection Process and Shaped by the Toll-Like Receptor/MyD88 Pathway

Humoral Responses Elicited by Adenovirus Displaying Epitopes Are Induced Independently of the Infection Process and Shaped by the Toll-Like Receptor/MyD88 Pathway

The use of serotype 5 adenovirus (Ad)-derived vectors in vaccination is confronted to preexisting anti-Ad immunity. Epitope display on Ad capsid is currently being investigated as an alternative approach of vaccination. The present study seeks to better understand virus- and host-related factors con...

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Bibliographic Details
Main Authors: Aleksandra Anchim, Najat Raddi, Lena Zig, Patrick Perrieau, Ronan Le Goffic, Bernhard Ryffel, Karim Benihoud
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Immunology
Subjects:
adenovirus
fiber
innate immunity
antibody isotype
MyD88
mitochondrial antiviral-signaling
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00124/full

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