Effect of irbesartan hydrochlorothiazide on endothelial function, hemodynamics and inflammatory response in hypertensive patients

• Main Authors: Chen-Yan Ge, Lin-Zhe Du, Xue-Meng Zhang
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2018-08-01
• Series: Journal of Hainan Medical University
• Subjects: Irbesartan hydrochlorothiazide; Hypertension; Endothelial function; Hemodynamics; Inflammatory reaction
• Online Access: http://www.hnykdxxb.com/PDF/201808/07.pdf

Objective: To observe the effect of irbesartan hydrochloride on endothelial function, hemodynamics and inflammatory response in patients with essential hypertension. Method: A total of 100 patients with essential hypertension admitted from May 2015 to August 2017 in our hospital were divided into observation group (50 cases) and control group (50 cases) according to random number table. The control group was treated with routine treatment, and the observation group was treated with erbesartan hydrochlorothiazide on the basis of routine treatment in the control group. The changes of vascular endothelial function, hemodynamics and inflammatory factors in the two groups were compared. Results: Before treatment, there was no significant difference in vWF, EDD and NMD levels, hemodynamics level and CRP, ICAM-1 and MCP-1 levels. After treatment, the vWF level in the observation group was significantly decreased and the EDD level was significantly increased; while the level of NMD was not significantly changed. After treatment, the level of vWF in the control group was significantly decreased; but there was no significant change in EDD and NMD level. After treatment, vWF level (144.94±16.21)% in the observation group was significantly lower than that in the control group; EDD level (6.81±0.74)% was significantly higher than that in the control group. After treatment, the levels of LBV, HBV and PV in the observation group were significantly lower than those before treatment, while the levels of LBV, HBV and PV in the control group were not significantly different from those before treatment. After treatment, LBV level (13.34±1.41) m.pas, HBV level (5.13±1.34) m.pas and PV level (1.65±0.34) m.pas in the observation group were significantly lower than those in the control group. After treatment, the levels of CRP, ICAM-1 and MCP-1 in both groups were significantly lower than those before treatment. After treatment, the level of CRP (1.71±0.81) mg/L, ICAM-1 level (330.82±68.51) ng/mL and MCP-1 level (3.02±1.06) g/L in the observation group were significantly lower than those in the control group. Conclusion: Irbesartan hydrochlorothiazide treatment of hypertension can play a significant role in the improvement of vascular endothelial function and hemorheology in patients, and can significantly reduce the level of inflammatory response in the body, worthy of clinical application.