Section 3. A Discussion of Flexible Dosing and Patient-Centered Therapy

Despite positive clinical experience and the published clinical benefits of monotherapy with low-or medium-dose inhaled corticosteroids or combination therapy with ICS + long-acting beta-agonist to treat asthma, many patients remain suboptimally controlled. Alternative approaches are needed, and 3 o...

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Main Authors:	G. Walter Canonica, MD, Christopher Brightling, MD
Format:	Article
Language:	English
Published:	Elsevier 2010-01-01
Series:	World Allergy Organization Journal
Online Access:	http://www.sciencedirect.com/science/article/pii/S193945511930465X

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spelling	doaj-a7813d705a8d4cf5b12023e1a4ae19832020-11-24T21:57:37ZengElsevierWorld Allergy Organization Journal1939-45512010-01-01323137Section 3. A Discussion of Flexible Dosing and Patient-Centered TherapyG. Walter Canonica, MD0Christopher Brightling, MD1Allergy and Respiratory Diseases Department, Genoa University, Genova, Italy; Corresponding author.Institute for Lung Health, University of Leicester, Leicester, United Kingdom; Corresponding author.Despite positive clinical experience and the published clinical benefits of monotherapy with low-or medium-dose inhaled corticosteroids or combination therapy with ICS + long-acting beta-agonist to treat asthma, many patients remain suboptimally controlled. Alternative approaches are needed, and 3 options that have had some success are: 1) using the patient's level of inflammation by established biomarkers to set treatment; 2) self-management incorporating flexible dosing; and 3) using a single inhaler for rescue and maintenance therapy. Which strategy for which patient depends ultimately on the individual patient's disease burden, life-style, comorbidities, preferences, and his or her ability to self-manage the disease, including assessing symptoms and adhering with therapy. Keywords: asthma, inhaled corticosteroid, flexible dosing, combination therapy, long-acting beta-agonisthttp://www.sciencedirect.com/science/article/pii/S193945511930465X
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	G. Walter Canonica, MD Christopher Brightling, MD
spellingShingle	G. Walter Canonica, MD Christopher Brightling, MD Section 3. A Discussion of Flexible Dosing and Patient-Centered Therapy World Allergy Organization Journal
author_facet	G. Walter Canonica, MD Christopher Brightling, MD
author_sort	G. Walter Canonica, MD
title	Section 3. A Discussion of Flexible Dosing and Patient-Centered Therapy
title_short	Section 3. A Discussion of Flexible Dosing and Patient-Centered Therapy
title_full	Section 3. A Discussion of Flexible Dosing and Patient-Centered Therapy
title_fullStr	Section 3. A Discussion of Flexible Dosing and Patient-Centered Therapy
title_full_unstemmed	Section 3. A Discussion of Flexible Dosing and Patient-Centered Therapy
title_sort	section 3. a discussion of flexible dosing and patient-centered therapy
publisher	Elsevier
series	World Allergy Organization Journal
issn	1939-4551
publishDate	2010-01-01
description	Despite positive clinical experience and the published clinical benefits of monotherapy with low-or medium-dose inhaled corticosteroids or combination therapy with ICS + long-acting beta-agonist to treat asthma, many patients remain suboptimally controlled. Alternative approaches are needed, and 3 options that have had some success are: 1) using the patient's level of inflammation by established biomarkers to set treatment; 2) self-management incorporating flexible dosing; and 3) using a single inhaler for rescue and maintenance therapy. Which strategy for which patient depends ultimately on the individual patient's disease burden, life-style, comorbidities, preferences, and his or her ability to self-manage the disease, including assessing symptoms and adhering with therapy. Keywords: asthma, inhaled corticosteroid, flexible dosing, combination therapy, long-acting beta-agonist
url	http://www.sciencedirect.com/science/article/pii/S193945511930465X
work_keys_str_mv	AT gwaltercanonicamd section3adiscussionofflexibledosingandpatientcenteredtherapy AT christopherbrightlingmd section3adiscussionofflexibledosingandpatientcenteredtherapy
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Section 3. A Discussion of Flexible Dosing and Patient-Centered Therapy

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