Novel Carboxylated Chitosan-Based Triptolide Conjugate for the Treatment of Rheumatoid Arthritis

Novel Carboxylated Chitosan-Based Triptolide Conjugate for the Treatment of Rheumatoid Arthritis

A new platform for triptolide (TP) delivery was prepared by conjugating TP to a carboxylmethyl chitosan (CMCS). Compared with the natural TP, the TP-conjugate (TP-CMCS) containing TP of ~5 wt% exhibited excellent aqueous solubility (> 5 mg/mL). Results of in vitro experiments showed that TP-C...

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Bibliographic Details
Main Authors: Lan Zhang, Min Yan, Kun Chen, Qikang Tian, Junying Song, Zijuan Zhang, Zhishen Xie, Yong Yuan, Yaquan Jia, Xin Zhu, Zhenqiang Zhang, Xiangxiang Wu, Huahui Zeng
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Pharmaceutics
Subjects:
triptolide
toxicity
water solubility
carboxylmethyl chitosan
drug carrier system
Online Access:https://www.mdpi.com/1999-4923/12/3/202

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