Signatures of host-pathogen evolutionary conflict reveal MISTR-A conserved MItochondrial STress Response network.

Host-pathogen conflicts leave genetic signatures in genes that are critical for host defense functions. Using these "molecular scars" as a guide to discover gene functions, we discovered a vertebrate-specific MItochondrial STress Response (MISTR) circuit. MISTR proteins are associated with...

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Bibliographic Details
Main Authors: Mahsa Sorouri, Tyron Chang, Palmy Jesudhasan, Chelsea Pinkham, Nels C Elde, Dustin C Hancks
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-12-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3001045