Extracellular mRNA transported to the nucleus exerts translation-independent function

Nonvesicular extracellular RNA (nex-RNA) that are not packed in extracellular vesicles is detected outside the cell, but it is poorly understood. Here the authors report that nex-RNA is captured by a zinc finger protein and transported to the nucleus to enhance antimetastatic characters of the cell.

Bibliographic Details
Main Authors:	Takeshi Tomita, Masayoshi Kato, Taishi Mishima, Yuta Matsunaga, Hideki Sanjo, Ken-ichi Ito, Kentaro Minagawa, Toshimitsu Matsui, Hiroyuki Oikawa, Satoshi Takahashi, Toshifumi Takao, Noriki Iwai, Takashi Mino, Osamu Takeuchi, Yoshiro Maru, Sachie Hiratsuka
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-23969-1

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spelling	doaj-a75fe0cb0a7242eda55465abbb5ce4d82021-06-20T11:12:42ZengNature Publishing GroupNature Communications2041-17232021-06-0112111910.1038/s41467-021-23969-1Extracellular mRNA transported to the nucleus exerts translation-independent functionTakeshi Tomita0Masayoshi Kato1Taishi Mishima2Yuta Matsunaga3Hideki Sanjo4Ken-ichi Ito5Kentaro Minagawa6Toshimitsu Matsui7Hiroyuki Oikawa8Satoshi Takahashi9Toshifumi Takao10Noriki Iwai11Takashi Mino12Osamu Takeuchi13Yoshiro Maru14Sachie Hiratsuka15Institute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University, School of MedicineInstitute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University, School of MedicineDepartment of Pharmacology, Tokyo Women’s Medical UniversityDepartment of Pharmacology, Tokyo Women’s Medical UniversityDepartment of Molecular and Cellular Immunology, Shinshu University, School of MedicineDivision of Breast, Endocrine and Respiratory Surgery, Department of Surgery, Shinshu University, School of MedicineDepartment of Hematology/Oncology, Penn State College of MedicineDepartment of Hematology, Nishiwaki Municipal HospitalInstitute of Multidisciplinary Research for Advanced Materials, Tohoku UniversityInstitute of Multidisciplinary Research for Advanced Materials, Tohoku UniversityInstitute for Protein Research, Osaka UniversityDepartment of Medical Chemistry, Graduate School of Medicine, Kyoto UniversityDepartment of Medical Chemistry, Graduate School of Medicine, Kyoto UniversityDepartment of Medical Chemistry, Graduate School of Medicine, Kyoto UniversityDepartment of Pharmacology, Tokyo Women’s Medical UniversityInstitute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University, School of MedicineNonvesicular extracellular RNA (nex-RNA) that are not packed in extracellular vesicles is detected outside the cell, but it is poorly understood. Here the authors report that nex-RNA is captured by a zinc finger protein and transported to the nucleus to enhance antimetastatic characters of the cell.https://doi.org/10.1038/s41467-021-23969-1
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Takeshi Tomita Masayoshi Kato Taishi Mishima Yuta Matsunaga Hideki Sanjo Ken-ichi Ito Kentaro Minagawa Toshimitsu Matsui Hiroyuki Oikawa Satoshi Takahashi Toshifumi Takao Noriki Iwai Takashi Mino Osamu Takeuchi Yoshiro Maru Sachie Hiratsuka
spellingShingle	Takeshi Tomita Masayoshi Kato Taishi Mishima Yuta Matsunaga Hideki Sanjo Ken-ichi Ito Kentaro Minagawa Toshimitsu Matsui Hiroyuki Oikawa Satoshi Takahashi Toshifumi Takao Noriki Iwai Takashi Mino Osamu Takeuchi Yoshiro Maru Sachie Hiratsuka Extracellular mRNA transported to the nucleus exerts translation-independent function Nature Communications
author_facet	Takeshi Tomita Masayoshi Kato Taishi Mishima Yuta Matsunaga Hideki Sanjo Ken-ichi Ito Kentaro Minagawa Toshimitsu Matsui Hiroyuki Oikawa Satoshi Takahashi Toshifumi Takao Noriki Iwai Takashi Mino Osamu Takeuchi Yoshiro Maru Sachie Hiratsuka
author_sort	Takeshi Tomita
title	Extracellular mRNA transported to the nucleus exerts translation-independent function
title_short	Extracellular mRNA transported to the nucleus exerts translation-independent function
title_full	Extracellular mRNA transported to the nucleus exerts translation-independent function
title_fullStr	Extracellular mRNA transported to the nucleus exerts translation-independent function
title_full_unstemmed	Extracellular mRNA transported to the nucleus exerts translation-independent function
title_sort	extracellular mrna transported to the nucleus exerts translation-independent function
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-06-01
description	Nonvesicular extracellular RNA (nex-RNA) that are not packed in extracellular vesicles is detected outside the cell, but it is poorly understood. Here the authors report that nex-RNA is captured by a zinc finger protein and transported to the nucleus to enhance antimetastatic characters of the cell.
url	https://doi.org/10.1038/s41467-021-23969-1
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Extracellular mRNA transported to the nucleus exerts translation-independent function

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