Extracellular mRNA transported to the nucleus exerts translation-independent function
Nonvesicular extracellular RNA (nex-RNA) that are not packed in extracellular vesicles is detected outside the cell, but it is poorly understood. Here the authors report that nex-RNA is captured by a zinc finger protein and transported to the nucleus to enhance antimetastatic characters of the cell.
Bibliographic Details
| Main Authors: |
Takeshi Tomita,
Masayoshi Kato,
Taishi Mishima,
Yuta Matsunaga,
Hideki Sanjo,
Ken-ichi Ito,
Kentaro Minagawa,
Toshimitsu Matsui,
Hiroyuki Oikawa,
Satoshi Takahashi,
Toshifumi Takao,
Noriki Iwai,
Takashi Mino,
Osamu Takeuchi,
Yoshiro Maru,
Sachie Hiratsuka |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2021-06-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-23969-1
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