Extra-telomeric functions of telomerase in the pathogenesis of Epstein-Barr virus-driven B-cell malignancies and potential therapeutic implications

Extra-telomeric functions of telomerase in the pathogenesis of Epstein-Barr virus-driven B-cell malignancies and potential therapeutic implications

Abstract The Epstein-Barr virus (EBV) is a ubiquitous human γ-herpesvirus causally linked to a broad spectrum of both lymphoid and epithelial malignancies. In order to maintain its persistence in host cells and promote tumorigenesis, EBV must restrict its lytic cycle, which would ultimately lead to...

Full description

Bibliographic Details
Main Authors: Silvia Giunco, Maria Raffaella Petrara, Manuela Zangrossi, Andrea Celeghin, Anita De Rossi
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Infectious Agents and Cancer
Subjects:
Telomerase
TERT extra-telomeric functions
Epstein-Barr virus
Latent/lytic viral cycle
B-cell malignancies
Online Access:http://link.springer.com/article/10.1186/s13027-018-0186-5

Similar Items

Similar Items