Fermentative Production of the Diamine Putrescine: System Metabolic Engineering of Corynebacterium Glutamicum

Fermentative Production of the Diamine Putrescine: System Metabolic Engineering of Corynebacterium Glutamicum

Corynebacterium glutamicum shows great potential for the production of the glutamate-derived diamine putrescine, a monomeric compound of polyamides. A genome-scale stoichiometric model of a C. glutamicum strain with reduced ornithine transcarbamoylase activity, derepressed arginine biosynthesis, and...

Full description

Bibliographic Details
Main Authors:	Anh Q. D. Nguyen, Jens Schneider, Gajendar Komati Reddy, Volker F. Wendisch
Format:	Article
Language:	English
Published:	MDPI AG 2015-04-01
Series:	Metabolites
Subjects:	diamine production putrescine Corynebacterium glutamicum 2-oxoglutatarate dehydrogenase pyruvate carboxylase glyceraldehyde 3-phosphate dehydrogenase OdhI spermidine N-acetyltransferase CgmR N-acetylglutamate kinase gamma-glutamate kinase genome-scale metabolic model flux balance analysis
Online Access:	http://www.mdpi.com/2218-1989/5/2/211

Similar Items

Equilibrium of the intracellular redox state for improving cell growth and l-lysine yield of Corynebacterium glutamicum by optimal cofactor swapping
by: Jian-Zhong Xu, et al.
Published: (2019-04-01)

Exploring Non-Metabolic Functions of Glycolytic Enzymes in Immunity
by: Scott M. Seki, et al.
Published: (2017-11-01)

An investigation of the effects of donor age on some haematological characteristics of the Wistar rat (Rattus Norwegicus)
by: Wesso, Iona
Published: (2021)

Transcriptomic Changes in Response to Putrescine Production in Metabolically Engineered Corynebacterium glutamicum
by: Zhen Li, et al.
Published: (2017-10-01)

Production of Biopolyamide Precursors 5-Amino Valeric Acid and Putrescine From Rice Straw Hydrolysate by Engineered Corynebacterium glutamicum
by: Keerthi Sasikumar, et al.
Published: (2021-03-01)

Evolution of the key alkaloid enzyme putrescine N-methyltransferase from spermidine synthase.
by: Anne eJunker, et al.
Published: (2013-07-01)

The Vibrio cholerae SpeG Spermidine/Spermine N-Acetyltransferase Allosteric Loop and β6-β7 Structural Elements Are Critical for Kinetic Activity
by: Van Thi Bich Le, et al.
Published: (2021-04-01)

Comprehensive Analysis of C. glutamicum Anaplerotic Deletion Mutants Under Defined d-Glucose Conditions
by: Jannick Kappelmann, et al.
Published: (2021-01-01)

The <i>ldhA</i> Gene Encoding Fermentative L-Lactate Dehydrogenase in <i>Corynebacterium glutamicum</i> Is Positively Regulated by the Global Regulator GlxR
by: Koichi Toyoda, et al.
Published: (2021-03-01)

The effect of polyamines and SICS on the compatibility, fertility and yield indices of apple cv. Golden Delicious
by: Pegah Sayyad-Amin, et al.
Published: (2018-04-01)

Polyamine metabolism changes in psoriasis
by: Valentina Broshtilova, et al.
Published: (2013-01-01)

Reducing lactate secretion by ldhA Deletion in L-glutamate- producing strain Corynebacterium glutamicum GDK-9
by: Dalong Zhang, et al.
Published: (2014-12-01)

Presentation and management of N-acetylglutamate synthase deficiency: a review of the literature
by: Aileen Kenneson, et al.
Published: (2020-10-01)

Probiotic-derived heptelidic acid exerts antitumor effects on extraintestinal melanoma through glyceraldehyde-3-phosphate dehydrogenase activity control
by: Fujiya, M., et al.
Published: (2022)

Role of <i>Staphylococcus aureus</i> GapC and GapB in immunity and pathogenesis of bovine mastitis
by: Kerro Dego, Oudessa
Published: (2009)

Piceatannol effectively counteracts glyceraldehyde-3-phosphate dehydrogenase aggregation and nuclear translocation in hippocampal cells
by: Joanna Gerszon, et al.
Published: (2019-07-01)

Real Time Monitoring of NADPH Concentrations in Corynebacterium glutamicum and Escherichia coli via the Genetically Encoded Sensor mBFP
by: Oliver Goldbeck, et al.
Published: (2018-10-01)

Thiamine mimetics sulbutiamine and benfotiamine as a nutraceutical approach to anticancer therapy
by: Hunter C. Jonus, et al.
Published: (2020-01-01)

Identification and application of a growth-regulated promoter for improving l-valine production in Corynebacterium glutamicum
by: Yuechao Ma, et al.
Published: (2018-11-01)

Application of the mammalian glyceraldehyde-3-phosphate dehydrogenase gene for sample quality control in multiplex PCR for diagnosis of leishmaniasis
by: SC Gonçalves, et al.
Published: (2012-01-01)

Étude de la biogénèse des lipoprotéines chez Corynebacterium glutamicum
by: Mohiman, Niloofar
Published: (2012)

Rational modification of tricarboxylic acid cycle for improving l-lysine production in Corynebacterium glutamicum
by: Jian-Zhong Xu, et al.
Published: (2018-07-01)

Phosphorylation of the PDH complex precedes HIF-1-mediated effects and PDK1 upregulation during the first hours of hypoxic treatment in HCC cells
by: Zimmer AD, et al.
Published: (2016-08-01)

Polyamines: Small Amines with Large Effects on Plant Abiotic Stress Tolerance
by: Rubén Alcázar, et al.
Published: (2020-10-01)

Dietary Polyamines Intake and Risk of Colorectal Cancer: A Case-Control Study
by: Chu-Yi Huang, et al.
Published: (2020-11-01)

Citrus Polyamines: Structure, Biosynthesis, and Physiological Functions
by: Nabil Killiny, et al.
Published: (2020-03-01)

Plant polyamines in stress and development: an emerging area of research in plant sciences.
by: Rubén eAlcázar, et al.
Published: (2014-07-01)

Polyamines in pollen: from microsporogenesis to fertilization
by: Iris eAloisi, et al.
Published: (2016-02-01)

Exogenous Polyamines Improve Mycorrhizal Development And Growth And Flowering Of Freesia hybrida
by: Rezvanypour Shirin, et al.
Published: (2015-12-01)

Exogenous spermidine affects polyamine metabolism in the mouse hypothalamus
by: Jiang Dongmei, et al.
Published: (2021-01-01)

Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers
by: Nam Ho Jeoung
Published: (2015-06-01)

Reconstruction of the Diaminopimelic Acid Pathway to Promote L-lysine Production in <i>Corynebacterium glutamicum</i>
by: Ning Liu, et al.
Published: (2021-08-01)

Determination of N-Carbamoylglutamate in Rumen Fluid
by: Bahram Chachar, et al.
Published: (2019-06-01)

Proton Transport Chains in Glucose Metabolism: Mind the Proton
by: Dirk Roosterman, et al.
Published: (2018-06-01)

Hydrogen peroxide as a signal mediator at inducing heat resistance in wheat seedlings by putrescine
by: Yu. E. Kolupaev, et al.
Published: (2019-12-01)

Tailoring Corynebacterium glutamicum towards increased malonyl-CoA availability for efficient synthesis of the plant pentaketide noreugenin
by: Lars Milke, et al.
Published: (2019-04-01)

Improvement of <span style="font-variant: small-caps">l</span>-Leucine Production in <i>Corynebacterium glutamicum</i> by Altering the Redox Flux
by: Ying-Yu Wang, et al.
Published: (2019-04-01)

Association of the biochemical parameters of ejaculate with the characteristics of spermatozoa
by: V. V. Evdokimov, et al.
Published: (2016-07-01)

Epitopes for Multivalent Vaccines Against Listeria, Mycobacterium and Streptococcus spp: A Novel Role for Glyceraldehyde-3-Phosphate Dehydrogenase
by: Carmen Alvarez-Dominguez, et al.
Published: (2020-10-01)

The glyceraldehyde-3-phosphate dehydrogenase gene of Moniliophthora perniciosa, the causal agent of witches' broom disease of Theobroma cacao
by: Juliana O. Lima, et al.
Published: (2009-01-01)