Investigation of base excision repair gene variants in late-onset Alzheimer's disease.

Investigation of base excision repair gene variants in late-onset Alzheimer's disease.

Base excision repair (BER) defects and concomitant oxidative DNA damage accumulation play a role in the etiology and progression of late-onset Alzheimer's disease (LOAD). However, it is not known whether genetic variant(s) of specific BER genes contribute to reduced BER activity in LOAD patient...

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Main Authors: Tugce Ertuzun, Asli Semerci, Mehmet Emin Cakir, Aysegul Ekmekcioglu, Mehmet Oguz Gok, Daniela T Soltys, Nadja C de Souza-Pinto, Ugur Sezerman, Meltem Muftuoglu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0221362

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