Evidence for Structural and Functional Alterations of Frontal-Executive and Corticolimbic Circuits in Late-Life Depression and Relationship to Mild Cognitive Impairment and Dementia: A Systematic Review

Evidence for Structural and Functional Alterations of Frontal-Executive and Corticolimbic Circuits in Late-Life Depression and Relationship to Mild Cognitive Impairment and Dementia: A Systematic Review

Depression is a risk factor for developing Alzheimer's disease and Related Dementia (ADRD). We conducted a systematic review between 2008 and October 2018, to evaluate the evidence for a conceptual mechanistic model linking depression and ADRD, focusing on frontal-executive and corticolimbic ci...

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Bibliographic Details
Main Authors: Neda Rashidi-Ranjbar, Dayton Miranda, Meryl A. Butters, Benoit H. Mulsant, Aristotle N. Voineskos
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Neuroscience
Subjects:
late-life depression
mild cognitive impairment
Alzheimer's disease
frontal-executive
corticolimbic
diffusion-tensor imaging
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00253/full

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