Extracellular Vesicles and Renal Fibrosis: An Odyssey toward a New Therapeutic Approach

Extracellular Vesicles and Renal Fibrosis: An Odyssey toward a New Therapeutic Approach

Renal fibrosis is a complex disorder characterized by the destruction of kidney parenchyma. There is currently no cure for this devastating condition. Extracellular vesicles (EVs) are membranous vesicles released from cells in both physiological and diseased states. Given their fundamental role in t...

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Main Authors: Maja Kosanović, Alicia Llorente, Sofija Glamočlija, José M. Valdivielso, Milica Bozic
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
extracellular vesicles
exosomes
cellular communication
renal fibrosis
CKD
therapeutic agents
Online Access:https://www.mdpi.com/1422-0067/22/8/3887
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spelling doaj-a74a013a577b44588db197f7b07d3d142021-04-09T23:02:54ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-04-01223887388710.3390/ijms22083887Extracellular Vesicles and Renal Fibrosis: An Odyssey toward a New Therapeutic ApproachMaja Kosanović0Alicia Llorente1Sofija Glamočlija2José M. Valdivielso3Milica Bozic4Institute for the Application of Nuclear Energy, INEP, University of Belgrade, 11080 Belgrade, SerbiaDepartment of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, 0379 Oslo, NorwayInstitute for the Application of Nuclear Energy, INEP, University of Belgrade, 11080 Belgrade, SerbiaVascular and Renal Translational Research Group, Institute for Biomedical Research in Lleida (IRBLleida) and RedInRen RETIC, 25196 Lleida, SpainDepartment of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, 0379 Oslo, NorwayRenal fibrosis is a complex disorder characterized by the destruction of kidney parenchyma. There is currently no cure for this devastating condition. Extracellular vesicles (EVs) are membranous vesicles released from cells in both physiological and diseased states. Given their fundamental role in transferring biomolecules to recipient cells and their ability to cross biological barriers, EVs have been widely investigated as potential cell-free therapeutic agents. In this review, we provide an overview of EVs, focusing on their functional role in renal fibrosis and signaling messengers responsible for EV-mediated crosstalk between various renal compartments. We explore recent findings regarding the renoprotective effect of EVs and their use as therapeutic agents in renal fibrosis. We also highlight advantages and future perspectives of the therapeutic applications of EVs in renal diseases.https://www.mdpi.com/1422-0067/22/8/3887extracellular vesiclesexosomescellular communicationrenal fibrosisCKDtherapeutic agents
collection DOAJ
language English
format Article
sources DOAJ
author Maja Kosanović
Alicia Llorente
Sofija Glamočlija
José M. Valdivielso
Milica Bozic
spellingShingle Maja Kosanović
Alicia Llorente
Sofija Glamočlija
José M. Valdivielso
Milica Bozic
Extracellular Vesicles and Renal Fibrosis: An Odyssey toward a New Therapeutic Approach
International Journal of Molecular Sciences
extracellular vesicles
exosomes
cellular communication
renal fibrosis
CKD
therapeutic agents
author_facet Maja Kosanović
Alicia Llorente
Sofija Glamočlija
José M. Valdivielso
Milica Bozic
author_sort Maja Kosanović
title Extracellular Vesicles and Renal Fibrosis: An Odyssey toward a New Therapeutic Approach
title_short Extracellular Vesicles and Renal Fibrosis: An Odyssey toward a New Therapeutic Approach
title_full Extracellular Vesicles and Renal Fibrosis: An Odyssey toward a New Therapeutic Approach
title_fullStr Extracellular Vesicles and Renal Fibrosis: An Odyssey toward a New Therapeutic Approach
title_full_unstemmed Extracellular Vesicles and Renal Fibrosis: An Odyssey toward a New Therapeutic Approach
title_sort extracellular vesicles and renal fibrosis: an odyssey toward a new therapeutic approach
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1661-6596
1422-0067
publishDate 2021-04-01
description Renal fibrosis is a complex disorder characterized by the destruction of kidney parenchyma. There is currently no cure for this devastating condition. Extracellular vesicles (EVs) are membranous vesicles released from cells in both physiological and diseased states. Given their fundamental role in transferring biomolecules to recipient cells and their ability to cross biological barriers, EVs have been widely investigated as potential cell-free therapeutic agents. In this review, we provide an overview of EVs, focusing on their functional role in renal fibrosis and signaling messengers responsible for EV-mediated crosstalk between various renal compartments. We explore recent findings regarding the renoprotective effect of EVs and their use as therapeutic agents in renal fibrosis. We also highlight advantages and future perspectives of the therapeutic applications of EVs in renal diseases.
topic extracellular vesicles
exosomes
cellular communication
renal fibrosis
CKD
therapeutic agents
url https://www.mdpi.com/1422-0067/22/8/3887
work_keys_str_mv AT majakosanovic extracellularvesiclesandrenalfibrosisanodysseytowardanewtherapeuticapproach
AT aliciallorente extracellularvesiclesandrenalfibrosisanodysseytowardanewtherapeuticapproach
AT sofijaglamoclija extracellularvesiclesandrenalfibrosisanodysseytowardanewtherapeuticapproach
AT josemvaldivielso extracellularvesiclesandrenalfibrosisanodysseytowardanewtherapeuticapproach
AT milicabozic extracellularvesiclesandrenalfibrosisanodysseytowardanewtherapeuticapproach
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