Additive influence of extracellular pH, oxygen tension, and pressure on invasiveness and survival of human osteosarcoma cells

Additive influence of extracellular pH, oxygen tension, and pressure on invasiveness and survival of human osteosarcoma cells

BACKGROUND/PURPOSE:The effects of chemical and physical interactions in the microenvironment of solid tumors have not been fully elucidated. We hypothesized that acidosis, hypoxia, and elevated interstitial fluid pressure (eIFP) have additive effects on tumor cell biology and lead to more aggressive...

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Bibliographic Details
Main Authors: Takao eMatsubara, Gene R. DiResta, Shigeki eKakunaga, Dasen eLi, John H. Healey
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-07-01
Series:Frontiers in Oncology
Subjects:
Osteosarcoma
Tumor Microenvironment
acidity
hypoxia
Carbonic Anhydrase IX
elevated interstitial fluid pressure
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00199/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00199/full

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