The zinc-finger protein Red1 orchestrates MTREC submodules and binds the Mtl1 helicase arch domain

The zinc-finger protein Red1 orchestrates MTREC submodules and binds the Mtl1 helicase arch domain

The human PAXT complex and the MTREC complex in fission yeast are important exosome cofactors, serving in the degradation of specific noncoding RNAs. Here, the authors combine structural, biochemical and in vivo methods to show how Red1 recruits the Mtl1 helicase by an interface not seen before in h...

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Main Authors: Nikolay Dobrev, Yasar Luqman Ahmed, Anusree Sivadas, Komal Soni, Tamás Fischer, Irmgard Sinning
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23565-3
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spelling doaj-a741735b27b946b7bd59c8534c1eb5c62021-06-13T11:16:18ZengNature Publishing GroupNature Communications2041-17232021-06-0112111310.1038/s41467-021-23565-3The zinc-finger protein Red1 orchestrates MTREC submodules and binds the Mtl1 helicase arch domainNikolay Dobrev0Yasar Luqman Ahmed1Anusree Sivadas2Komal Soni3Tamás Fischer4Irmgard Sinning5Heidelberg University Biochemistry Center (BZH)Heidelberg University Biochemistry Center (BZH)The John Curtin School of Medical Research, The Australian National UniversityHeidelberg University Biochemistry Center (BZH)Heidelberg University Biochemistry Center (BZH)Heidelberg University Biochemistry Center (BZH)The human PAXT complex and the MTREC complex in fission yeast are important exosome cofactors, serving in the degradation of specific noncoding RNAs. Here, the authors combine structural, biochemical and in vivo methods to show how Red1 recruits the Mtl1 helicase by an interface not seen before in helicase-adaptor complexes.https://doi.org/10.1038/s41467-021-23565-3
collection DOAJ
language English
format Article
sources DOAJ
author Nikolay Dobrev
Yasar Luqman Ahmed
Anusree Sivadas
Komal Soni
Tamás Fischer
Irmgard Sinning
spellingShingle Nikolay Dobrev
Yasar Luqman Ahmed
Anusree Sivadas
Komal Soni
Tamás Fischer
Irmgard Sinning
The zinc-finger protein Red1 orchestrates MTREC submodules and binds the Mtl1 helicase arch domain
Nature Communications
author_facet Nikolay Dobrev
Yasar Luqman Ahmed
Anusree Sivadas
Komal Soni
Tamás Fischer
Irmgard Sinning
author_sort Nikolay Dobrev
title The zinc-finger protein Red1 orchestrates MTREC submodules and binds the Mtl1 helicase arch domain
title_short The zinc-finger protein Red1 orchestrates MTREC submodules and binds the Mtl1 helicase arch domain
title_full The zinc-finger protein Red1 orchestrates MTREC submodules and binds the Mtl1 helicase arch domain
title_fullStr The zinc-finger protein Red1 orchestrates MTREC submodules and binds the Mtl1 helicase arch domain
title_full_unstemmed The zinc-finger protein Red1 orchestrates MTREC submodules and binds the Mtl1 helicase arch domain
title_sort zinc-finger protein red1 orchestrates mtrec submodules and binds the mtl1 helicase arch domain
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-06-01
description The human PAXT complex and the MTREC complex in fission yeast are important exosome cofactors, serving in the degradation of specific noncoding RNAs. Here, the authors combine structural, biochemical and in vivo methods to show how Red1 recruits the Mtl1 helicase by an interface not seen before in helicase-adaptor complexes.
url https://doi.org/10.1038/s41467-021-23565-3
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