Hierarchical tissue organization as a general mechanism to limit the accumulation of somatic mutations

Hierarchical tissue organization as a general mechanism to limit the accumulation of somatic mutations

To limit the accumulation of somatic mutations, renewing tissues must minimize the number of times each cell divides during differentiation. Here, the authors analytically derive the lower limit of lifetime divisional load of a tissue, show that hierarchically differentiating tissues can approach th...

Full description

Bibliographic Details
Main Authors: Imre Derényi, Gergely J. Szöllősi
Format: Article
Language:English
Published: Nature Publishing Group 2017-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms14545
id doaj-a73bfd5d10674b91ad5f4d27c0ecfe16
record_format Article
spelling doaj-a73bfd5d10674b91ad5f4d27c0ecfe162021-05-11T07:37:40ZengNature Publishing GroupNature Communications2041-17232017-02-01811810.1038/ncomms14545Hierarchical tissue organization as a general mechanism to limit the accumulation of somatic mutationsImre Derényi0Gergely J. Szöllősi1Department of Biological Physics, ELTE-MTA ‘Lendulet’ Biophysics Research Group, Eötvös UniversityDepartment of Biological Physics, ELTE-MTA ‘Lendulet’ Evolutionary Genomics Research Group, Eötvös UniversityTo limit the accumulation of somatic mutations, renewing tissues must minimize the number of times each cell divides during differentiation. Here, the authors analytically derive the lower limit of lifetime divisional load of a tissue, show that hierarchically differentiating tissues can approach this limit, and that this depends on uneven divisional rates across the hierarchy.https://doi.org/10.1038/ncomms14545
collection DOAJ
language English
format Article
sources DOAJ
author Imre Derényi
Gergely J. Szöllősi
spellingShingle Imre Derényi
Gergely J. Szöllősi
Hierarchical tissue organization as a general mechanism to limit the accumulation of somatic mutations
Nature Communications
author_facet Imre Derényi
Gergely J. Szöllősi
author_sort Imre Derényi
title Hierarchical tissue organization as a general mechanism to limit the accumulation of somatic mutations
title_short Hierarchical tissue organization as a general mechanism to limit the accumulation of somatic mutations
title_full Hierarchical tissue organization as a general mechanism to limit the accumulation of somatic mutations
title_fullStr Hierarchical tissue organization as a general mechanism to limit the accumulation of somatic mutations
title_full_unstemmed Hierarchical tissue organization as a general mechanism to limit the accumulation of somatic mutations
title_sort hierarchical tissue organization as a general mechanism to limit the accumulation of somatic mutations
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-02-01
description To limit the accumulation of somatic mutations, renewing tissues must minimize the number of times each cell divides during differentiation. Here, the authors analytically derive the lower limit of lifetime divisional load of a tissue, show that hierarchically differentiating tissues can approach this limit, and that this depends on uneven divisional rates across the hierarchy.
url https://doi.org/10.1038/ncomms14545
work_keys_str_mv AT imrederenyi hierarchicaltissueorganizationasageneralmechanismtolimittheaccumulationofsomaticmutations
AT gergelyjszollosi hierarchicaltissueorganizationasageneralmechanismtolimittheaccumulationofsomaticmutations
_version_ 1721451919255273472

Similar Items