Diagnosis of Brain Tumors Using Amino Acid Transport PET Imaging With 18F- Fluciclovine: A Comparison Study With L-Methyl-11C-Methionine PET Imaging

Objective(s): 18F-fluciclovine (trans-1-amino-3-[18F] fluorocyclobutanecarboxylic acid, [FACBC]) is an artificial amino acid radiotracer used for positron emission tomography (PET) studies, which is metabolically stable in vivo and has a long half-life. It has already been shown that FACBC-PET is us...

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Main Authors: Naohiro Tsuyuguchi, Yuzo Terakawa, Takehiro Uda, Kosuke Nakajo, Yonehiro Kanemura
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2017-06-01
Series:Asia Oceania Journal of Nuclear Medicine and Biology
Subjects:
Online Access:http://aojnmb.mums.ac.ir/article_8843_ddd1cf6ad0e4feca502f8684ebde2f6c.pdf
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spelling doaj-a730e02928fa417ebb16ce850312b66c2020-11-25T03:18:13ZengMashhad University of Medical SciencesAsia Oceania Journal of Nuclear Medicine and Biology2322-57182322-57262017-06-0152869610.22038/aojnmb.2017.88438843Diagnosis of Brain Tumors Using Amino Acid Transport PET Imaging With 18F- Fluciclovine: A Comparison Study With L-Methyl-11C-Methionine PET ImagingNaohiro Tsuyuguchi0Yuzo Terakawa1Takehiro Uda2Kosuke Nakajo3Yonehiro Kanemura4Department of Neurosurgery, Osaka City University Graduate School of Medicine, Osaka, JapanDepartment of Neurosurgery, Hokkaido Oono Memorial Hospital, Osaka, JapanDepartment of Neurosurgery, Osaka City University Graduate School of Medicine, Osaka, JapanDepartment of Neurosurgery, Osaka City University Graduate School of Medicine, Osaka, JapanDepartment of neurosyrgery, Kansai Molecular Diagnosis Network for CNS Tumors, Osaka National Hospital, Osaka, JapanObjective(s): 18F-fluciclovine (trans-1-amino-3-[18F] fluorocyclobutanecarboxylic acid, [FACBC]) is an artificial amino acid radiotracer used for positron emission tomography (PET) studies, which is metabolically stable in vivo and has a long half-life. It has already been shown that FACBC-PET is useful for glioma imaging. However, there have been no reports evaluating the efficiency of FACBC-PET in the diagnosis of brain tumors in comparison with other PET tracers in clinical studies. The purpose of this study was to investigate the efficacy of FACBC-PET imaging in glioma diagnosis, compared to l-methyl-11C-methionine (MET)-PET.Methods: Six consecutive patients (four male, two female), who were clinically suspected of having high- or low-grade glioma, received both FACBC-PET and MET-PET within a two-week interval. T1-weighted, contrast-enhanced, T1-weighted, and fluid-attenuated inversion recovery magnetic resonance imaging was performed to assist with subsequent tissue resection. Visual findings and semi-quantitative analyses of FACBC and MET uptake, using standardized uptake values (SUVs) and lesion-to-contralateral normal brain tissue (LN) ratios, were evaluated to compare PET images.Results: SUVs for FACBC were lower than those for MET in the non-lesion cerebral cortex, brain stem, and cerebellar hemisphere. There was a weak positive correlation between FACBC and MET uptake in glioma tissue, although L/N ratios for FACBC were higher than those for MET in all the cases.Conclusion: FACBC-PET showed higher contrast than MET-PET by both visual and semi-quantitative analyses and may therefore provide better assessment for the detection of glioma. This study was registered as clinical trial (No. JapicCTI-132289).http://aojnmb.mums.ac.ir/article_8843_ddd1cf6ad0e4feca502f8684ebde2f6c.pdf11C-Methionine18F-fluciclovineGliomaPositron emission tomography
collection DOAJ
language English
format Article
sources DOAJ
author Naohiro Tsuyuguchi
Yuzo Terakawa
Takehiro Uda
Kosuke Nakajo
Yonehiro Kanemura
spellingShingle Naohiro Tsuyuguchi
Yuzo Terakawa
Takehiro Uda
Kosuke Nakajo
Yonehiro Kanemura
Diagnosis of Brain Tumors Using Amino Acid Transport PET Imaging With 18F- Fluciclovine: A Comparison Study With L-Methyl-11C-Methionine PET Imaging
Asia Oceania Journal of Nuclear Medicine and Biology
11C-Methionine
18F-fluciclovine
Glioma
Positron emission tomography
author_facet Naohiro Tsuyuguchi
Yuzo Terakawa
Takehiro Uda
Kosuke Nakajo
Yonehiro Kanemura
author_sort Naohiro Tsuyuguchi
title Diagnosis of Brain Tumors Using Amino Acid Transport PET Imaging With 18F- Fluciclovine: A Comparison Study With L-Methyl-11C-Methionine PET Imaging
title_short Diagnosis of Brain Tumors Using Amino Acid Transport PET Imaging With 18F- Fluciclovine: A Comparison Study With L-Methyl-11C-Methionine PET Imaging
title_full Diagnosis of Brain Tumors Using Amino Acid Transport PET Imaging With 18F- Fluciclovine: A Comparison Study With L-Methyl-11C-Methionine PET Imaging
title_fullStr Diagnosis of Brain Tumors Using Amino Acid Transport PET Imaging With 18F- Fluciclovine: A Comparison Study With L-Methyl-11C-Methionine PET Imaging
title_full_unstemmed Diagnosis of Brain Tumors Using Amino Acid Transport PET Imaging With 18F- Fluciclovine: A Comparison Study With L-Methyl-11C-Methionine PET Imaging
title_sort diagnosis of brain tumors using amino acid transport pet imaging with 18f- fluciclovine: a comparison study with l-methyl-11c-methionine pet imaging
publisher Mashhad University of Medical Sciences
series Asia Oceania Journal of Nuclear Medicine and Biology
issn 2322-5718
2322-5726
publishDate 2017-06-01
description Objective(s): 18F-fluciclovine (trans-1-amino-3-[18F] fluorocyclobutanecarboxylic acid, [FACBC]) is an artificial amino acid radiotracer used for positron emission tomography (PET) studies, which is metabolically stable in vivo and has a long half-life. It has already been shown that FACBC-PET is useful for glioma imaging. However, there have been no reports evaluating the efficiency of FACBC-PET in the diagnosis of brain tumors in comparison with other PET tracers in clinical studies. The purpose of this study was to investigate the efficacy of FACBC-PET imaging in glioma diagnosis, compared to l-methyl-11C-methionine (MET)-PET.Methods: Six consecutive patients (four male, two female), who were clinically suspected of having high- or low-grade glioma, received both FACBC-PET and MET-PET within a two-week interval. T1-weighted, contrast-enhanced, T1-weighted, and fluid-attenuated inversion recovery magnetic resonance imaging was performed to assist with subsequent tissue resection. Visual findings and semi-quantitative analyses of FACBC and MET uptake, using standardized uptake values (SUVs) and lesion-to-contralateral normal brain tissue (LN) ratios, were evaluated to compare PET images.Results: SUVs for FACBC were lower than those for MET in the non-lesion cerebral cortex, brain stem, and cerebellar hemisphere. There was a weak positive correlation between FACBC and MET uptake in glioma tissue, although L/N ratios for FACBC were higher than those for MET in all the cases.Conclusion: FACBC-PET showed higher contrast than MET-PET by both visual and semi-quantitative analyses and may therefore provide better assessment for the detection of glioma. This study was registered as clinical trial (No. JapicCTI-132289).
topic 11C-Methionine
18F-fluciclovine
Glioma
Positron emission tomography
url http://aojnmb.mums.ac.ir/article_8843_ddd1cf6ad0e4feca502f8684ebde2f6c.pdf
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