Long Non-coding RNA TDRKH-AS1 Promotes Colorectal Cancer Cell Proliferation and Invasion Through the β-Catenin Activated Wnt Signaling Pathway

Long Non-coding RNA TDRKH-AS1 Promotes Colorectal Cancer Cell Proliferation and Invasion Through the β-Catenin Activated Wnt Signaling Pathway

Colorectal cancer (CRC) is a common cancer worldwide, with a lower 5-years survival rate. Recently, long non-coding RNAs (lncRNAs) have been well-studied as the oncogenes or the tumor suppressors in multiple malignancies, including CRC. However, their biological functions and potential mechanisms in...

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Main Authors: Yang Jiao, Jialiang Zhou, Yecheng Jin, Yingxin Yang, Mingxu Song, Ling Zhang, Jiayan Zhou, Jiwei Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Oncology
Subjects:
colorectal cancer
TDRKH-AS1
Wnt signal pathway
β-catenin
TCGA
RNA sequencing analysis
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00639/full
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spelling doaj-a72ffd35b903409f910e9de9a73e2e772020-11-25T02:59:12ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-05-011010.3389/fonc.2020.00639530716Long Non-coding RNA TDRKH-AS1 Promotes Colorectal Cancer Cell Proliferation and Invasion Through the β-Catenin Activated Wnt Signaling PathwayYang Jiao0Jialiang Zhou1Yecheng Jin2Yingxin Yang3Mingxu Song4Ling Zhang5Jiayan Zhou6Jiayan Zhou7Jiwei Zhang8College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, ChinaThe Affiliated Hospital of Jiangnan University, Wuxi, ChinaAffiliated Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaAffiliated Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaThe Affiliated Hospital of Jiangnan University, Wuxi, ChinaCollege of Life Science, Zhejiang Chinese Medical University, Hangzhou, ChinaDepartment of Veterinary and Biomedical Sciences, College of Agricultural Sciences, The Pennsylvania State University, University Park, PA, United StatesDepartment of Statistics, Eberly College of Science, The Pennsylvania State University, University Park, PA, United StatesThe MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaColorectal cancer (CRC) is a common cancer worldwide, with a lower 5-years survival rate. Recently, long non-coding RNAs (lncRNAs) have been well-studied as the oncogenes or the tumor suppressors in multiple malignancies, including CRC. However, their biological functions and potential mechanisms in human cancer remain unclear. Here, we evaluated the expression of TDRKH-AS1 in CRC tissues and identified its potential targets. We found that TDRKH-AS1 is upregulated in majority of CRC patients, which is also significantly correlated with their malignant characteristics and their dismal prognoses. The high expression of TDRKH-AS1 can promote cancer cell proliferation substantially and invasion based on in vitro experiments. We also recognized that the TDRKH-AS1 targets the β-catenin in the Wnt signaling pathway to exert its carcinogenic activity. TDRKH-AS1 could serve as a promising prognostic predictor and a potential therapeutic target for further early diagnoses and treatments via a non-invasive method.https://www.frontiersin.org/article/10.3389/fonc.2020.00639/fullcolorectal cancerTDRKH-AS1Wnt signal pathwayβ-cateninTCGARNA sequencing analysis
collection DOAJ
language English
format Article
sources DOAJ
author Yang Jiao
Jialiang Zhou
Yecheng Jin
Yingxin Yang
Mingxu Song
Ling Zhang
Jiayan Zhou
Jiayan Zhou
Jiwei Zhang
spellingShingle Yang Jiao
Jialiang Zhou
Yecheng Jin
Yingxin Yang
Mingxu Song
Ling Zhang
Jiayan Zhou
Jiayan Zhou
Jiwei Zhang
Long Non-coding RNA TDRKH-AS1 Promotes Colorectal Cancer Cell Proliferation and Invasion Through the β-Catenin Activated Wnt Signaling Pathway
Frontiers in Oncology
colorectal cancer
TDRKH-AS1
Wnt signal pathway
β-catenin
TCGA
RNA sequencing analysis
author_facet Yang Jiao
Jialiang Zhou
Yecheng Jin
Yingxin Yang
Mingxu Song
Ling Zhang
Jiayan Zhou
Jiayan Zhou
Jiwei Zhang
author_sort Yang Jiao
title Long Non-coding RNA TDRKH-AS1 Promotes Colorectal Cancer Cell Proliferation and Invasion Through the β-Catenin Activated Wnt Signaling Pathway
title_short Long Non-coding RNA TDRKH-AS1 Promotes Colorectal Cancer Cell Proliferation and Invasion Through the β-Catenin Activated Wnt Signaling Pathway
title_full Long Non-coding RNA TDRKH-AS1 Promotes Colorectal Cancer Cell Proliferation and Invasion Through the β-Catenin Activated Wnt Signaling Pathway
title_fullStr Long Non-coding RNA TDRKH-AS1 Promotes Colorectal Cancer Cell Proliferation and Invasion Through the β-Catenin Activated Wnt Signaling Pathway
title_full_unstemmed Long Non-coding RNA TDRKH-AS1 Promotes Colorectal Cancer Cell Proliferation and Invasion Through the β-Catenin Activated Wnt Signaling Pathway
title_sort long non-coding rna tdrkh-as1 promotes colorectal cancer cell proliferation and invasion through the β-catenin activated wnt signaling pathway
publisher Frontiers Media S.A.
series Frontiers in Oncology
issn 2234-943X
publishDate 2020-05-01
description Colorectal cancer (CRC) is a common cancer worldwide, with a lower 5-years survival rate. Recently, long non-coding RNAs (lncRNAs) have been well-studied as the oncogenes or the tumor suppressors in multiple malignancies, including CRC. However, their biological functions and potential mechanisms in human cancer remain unclear. Here, we evaluated the expression of TDRKH-AS1 in CRC tissues and identified its potential targets. We found that TDRKH-AS1 is upregulated in majority of CRC patients, which is also significantly correlated with their malignant characteristics and their dismal prognoses. The high expression of TDRKH-AS1 can promote cancer cell proliferation substantially and invasion based on in vitro experiments. We also recognized that the TDRKH-AS1 targets the β-catenin in the Wnt signaling pathway to exert its carcinogenic activity. TDRKH-AS1 could serve as a promising prognostic predictor and a potential therapeutic target for further early diagnoses and treatments via a non-invasive method.
topic colorectal cancer
TDRKH-AS1
Wnt signal pathway
β-catenin
TCGA
RNA sequencing analysis
url https://www.frontiersin.org/article/10.3389/fonc.2020.00639/full
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AT jiweizhang longnoncodingrnatdrkhas1promotescolorectalcancercellproliferationandinvasionthroughthebcateninactivatedwntsignalingpathway
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