Mast Cells Induce Blood Brain Barrier Damage in SCD by Causing Endoplasmic Reticulum Stress in the Endothelium

Mast Cells Induce Blood Brain Barrier Damage in SCD by Causing Endoplasmic Reticulum Stress in the Endothelium

Endothelial dysfunction underlies the pathobiology of cerebrovascular disease. Mast cells are located in close proximity to the vasculature, and vasoactive mediators released upon their activation can promote endothelial activation leading to blood brain barrier (BBB) dysfunction. We examined the me...

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Bibliographic Details
Main Authors: Huy Tran, Aditya Mittal, Varun Sagi, Kathryn Luk, Aithanh Nguyen, Mihir Gupta, Julia Nguyen, Yann Lamarre, Jianxun Lei, Alonso Guedes, Kalpna Gupta
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
blood brain barrier
endoplasmic reticulum stress
endothelial cell
mast cell
P-selectin
sickle cell disease
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00056/full

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