Sequestosome 1 Deficiency Delays, but Does Not Prevent Brain Damage Formation Following Acute Brain Injury in Adult Mice

Sequestosome 1 Deficiency Delays, but Does Not Prevent Brain Damage Formation Following Acute Brain Injury in Adult Mice

Neuronal degeneration following traumatic brain injury (TBI) leads to intracellular accumulation of dysfunctional proteins and organelles. Autophagy may serve to facilitate degradation to overcome protein debris load and therefore be an important pro-survival factor. On the contrary, clearing may se...

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Bibliographic Details
Main Authors: Anne Sebastiani, Christina Gölz, Philipp G. Sebastiani, Wiesia Bobkiewicz, Christian Behl, Thomas Mittmann, Serge C. Thal, Kristin Engelhard
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Neuroscience
Subjects:
traumatic brain injury
protein degradation
autophagy
SQSTM1
p62
BAG3
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2017.00678/full

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