Automated discovery of novel drug formulations using predictive iterated high throughput experimentation.

Automated discovery of novel drug formulations using predictive iterated high throughput experimentation.

BACKGROUND: We consider the problem of optimizing a liposomal drug formulation: a complex chemical system with many components (e.g., elements of a lipid library) that interact nonlinearly and synergistically in ways that cannot be predicted from first principles. METHODOLOGY/PRINCIPAL FINDINGS: The...

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Bibliographic Details
Main Authors: Filippo Caschera, Gianluca Gazzola, Mark A Bedau, Carolina Bosch Moreno, Andrew Buchanan, James Cawse, Norman Packard, Martin M Hanczyc
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2797296?pdf=render

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