A pilot study investigating the use of 4D flow MRI for the assessment of splanchnic flow in patients suspected of mesenteric ischaemia

Abstract The most common cause of chronic mesenteric ischaemia is atherosclerosis which results in limitation of blood flow to the gastrointestinal tract. This pilot study aimed to evaluate 4D flow MRI as a potential tool for the analysis of blood flow changes post-prandial within the mesenteric ves...

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Main Authors: Pauline Hall Barrientos, Katrina Knight, Douglas Black, Alexander Vesey, Giles Roditi
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-85315-1
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spelling doaj-a6deddba3b874f76bb9f723ba1d749002021-03-21T12:35:40ZengNature Publishing GroupScientific Reports2045-23222021-03-011111910.1038/s41598-021-85315-1A pilot study investigating the use of 4D flow MRI for the assessment of splanchnic flow in patients suspected of mesenteric ischaemiaPauline Hall Barrientos0Katrina Knight1Douglas Black2Alexander Vesey3Giles Roditi4Clinical Physics, Queen Elizabeth University Hospital, NHS Greater Glasgow & ClydeAcademic Unit of Surgery, Glasgow Royal Infirmary, NHS Greater Glasgow & ClydeDepartment of Radiology, NHS Greater Glasgow & Clyde & Institute of Cardiovascular and Medical SciencesDepartment Vascular Surgery, University Hospital HairmyresDepartment of Radiology, NHS Greater Glasgow & Clyde & Institute of Cardiovascular and Medical SciencesAbstract The most common cause of chronic mesenteric ischaemia is atherosclerosis which results in limitation of blood flow to the gastrointestinal tract. This pilot study aimed to evaluate 4D flow MRI as a potential tool for the analysis of blood flow changes post-prandial within the mesenteric vessels. The mesenteric vessels of twelve people were scanned; patients and healthy volunteers. A baseline MRI scan was performed after 6 h of fasting followed by a post-meal scan. Two 4D flow datasets were acquired, over the superior mesenteric artery (SMA) and the main portal venous vessels. Standard 2D time-resolved PC-MRI slices were also obtained across the aorta above the coeliac trunk, superior mesenteric vein, splenic vein and portal vein (PV). In the volunteer cohort there was a marked increase in blood flow post-meal within the PV (p = 0.028), not seen in the patient cohort (p = 0.116). Similarly, there were significant flow changes within the SMA of volunteers (p = 0.028) but not for the patient group (p = 0.116). Our pilot data has shown that there is a significant haemodynamic response to meal challenge in the PV and SMA in normal subjects compared to clinically apparent CMI patients. Therefore, the interrogation of mesenteric venous vessels exclusively is a feasible method to measure post-prandial flow changes in CMI patients.https://doi.org/10.1038/s41598-021-85315-1
collection DOAJ
language English
format Article
sources DOAJ
author Pauline Hall Barrientos
Katrina Knight
Douglas Black
Alexander Vesey
Giles Roditi
spellingShingle Pauline Hall Barrientos
Katrina Knight
Douglas Black
Alexander Vesey
Giles Roditi
A pilot study investigating the use of 4D flow MRI for the assessment of splanchnic flow in patients suspected of mesenteric ischaemia
Scientific Reports
author_facet Pauline Hall Barrientos
Katrina Knight
Douglas Black
Alexander Vesey
Giles Roditi
author_sort Pauline Hall Barrientos
title A pilot study investigating the use of 4D flow MRI for the assessment of splanchnic flow in patients suspected of mesenteric ischaemia
title_short A pilot study investigating the use of 4D flow MRI for the assessment of splanchnic flow in patients suspected of mesenteric ischaemia
title_full A pilot study investigating the use of 4D flow MRI for the assessment of splanchnic flow in patients suspected of mesenteric ischaemia
title_fullStr A pilot study investigating the use of 4D flow MRI for the assessment of splanchnic flow in patients suspected of mesenteric ischaemia
title_full_unstemmed A pilot study investigating the use of 4D flow MRI for the assessment of splanchnic flow in patients suspected of mesenteric ischaemia
title_sort pilot study investigating the use of 4d flow mri for the assessment of splanchnic flow in patients suspected of mesenteric ischaemia
publisher Nature Publishing Group
series Scientific Reports
issn 2045-2322
publishDate 2021-03-01
description Abstract The most common cause of chronic mesenteric ischaemia is atherosclerosis which results in limitation of blood flow to the gastrointestinal tract. This pilot study aimed to evaluate 4D flow MRI as a potential tool for the analysis of blood flow changes post-prandial within the mesenteric vessels. The mesenteric vessels of twelve people were scanned; patients and healthy volunteers. A baseline MRI scan was performed after 6 h of fasting followed by a post-meal scan. Two 4D flow datasets were acquired, over the superior mesenteric artery (SMA) and the main portal venous vessels. Standard 2D time-resolved PC-MRI slices were also obtained across the aorta above the coeliac trunk, superior mesenteric vein, splenic vein and portal vein (PV). In the volunteer cohort there was a marked increase in blood flow post-meal within the PV (p = 0.028), not seen in the patient cohort (p = 0.116). Similarly, there were significant flow changes within the SMA of volunteers (p = 0.028) but not for the patient group (p = 0.116). Our pilot data has shown that there is a significant haemodynamic response to meal challenge in the PV and SMA in normal subjects compared to clinically apparent CMI patients. Therefore, the interrogation of mesenteric venous vessels exclusively is a feasible method to measure post-prandial flow changes in CMI patients.
url https://doi.org/10.1038/s41598-021-85315-1
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