Prognostic Markers in Chondrosarcoma: Evaluation of Cell Proliferation and of Regulators of the Cell Cycle
Purpose. The prognosis, treatment principles and prediction of clinical outcome of patients with chondrosarcoma currently rest on histologic grading which is somewhat ambiguous due to difficulty in pathologic interpretation of this neoplasm. Immunohistochemistry, flow cytometry and oncogene/tumor su...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
1997-01-01
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| Series: | Sarcoma |
| Online Access: | http://dx.doi.org/10.1080/13577149778344 |
| Summary: | Purpose. The prognosis, treatment principles and prediction of clinical outcome of patients with chondrosarcoma
currently rest on histologic grading which is somewhat ambiguous due to difficulty in pathologic interpretation of this
neoplasm. Immunohistochemistry, flow cytometry and oncogene/tumor suppressor gene expression have been examined
as alternative indices to predict the biologic behavior of these tumors. Because of partial successes obtained with flow
cytometry and because of the improvement in predicting recurrence offered by examining the S-phase fraction, we
undertook the current study to determine if expression of specific regulators of the cell cycle would act as prognostic
indicators for these patients. |
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| ISSN: | 1357-714X 1369-1643 |