CD4 T-cell immune stimulation of HER2 + breast cancer cells alters response to trastuzumab in vitro

CD4 T-cell immune stimulation of HER2 + breast cancer cells alters response to trastuzumab in vitro

Abstract Introduction The HER2 + tumor immune microenvironment is composed of macrophages, natural killer cells, and tumor infiltrating lymphocytes, which produce pro-inflammatory cytokines. Determining the effect of T-cells on HER2 + cancer cells during therapy could guide immunogenic therapies tha...

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Bibliographic Details
Main Authors: Patrick N. Song, Ameer Mansur, Kari J. Dugger, Tessa R. Davis, Grant Howard, Thomas E. Yankeelov, Anna G. Sorace
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Cancer Cell International
Subjects:
CD4 + T-cell
Co-culture
Herceptin
Live-cell imaging
TNF-α
Online Access:http://link.springer.com/article/10.1186/s12935-020-01625-w

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