Genipin and insulin combined treatment improves implant osseointegration in type 2 diabetic rats

Genipin and insulin combined treatment improves implant osseointegration in type 2 diabetic rats

Abstract Background Type 2 diabetes mellitus (T2DM) has a harmful effect on the stability and osseointegration of dental implants. T2DM induces mitochondrial damage by inhibiting AMPK signaling, resulting in oxidative stress and poor osteogenesis in the peri-implant bone area. Genipin is a major com...

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Bibliographic Details
Main Authors:	Jiajia Zhang, Ya-nan Wang, Tingting Jia, Haiyun Huang, Dongjiao Zhang, Xin Xu
Format:	Article
Language:	English
Published:	BMC 2021-01-01
Series:	Journal of Orthopaedic Surgery and Research
Subjects:	Type 2 diabetes mellitus (T2DM) Genipin Insulin Osseointegration Oxidative stress Adenosine 5′-monophosphate-activated protein kinase (AMPK)
Online Access:	https://doi.org/10.1186/s13018-021-02210-1

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