Impaired vascular contractility and aortic wall degeneration in fibulin-4 deficient mice: effect of angiotensin II type 1 (AT1) receptor blockade.

Impaired vascular contractility and aortic wall degeneration in fibulin-4 deficient mice: effect of angiotensin II type 1 (AT1) receptor blockade.

Medial degeneration is a key feature of aneurysm disease and aortic dissection. In a murine aneurysm model we investigated the structural and functional characteristics of aortic wall degeneration in adult fibulin-4 deficient mice and the potential therapeutic role of the angiotensin (Ang) II type 1...

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Bibliographic Details
Main Authors: Els Moltzer, Luuk te Riet, Sigrid M A Swagemakers, Paula M van Heijningen, Marcel Vermeij, Richard van Veghel, Angelique M Bouhuizen, Joep H M van Esch, Stephanie Lankhorst, Natasja W M Ramnath, Monique C de Waard, Dirk J Duncker, Peter J van der Spek, Ellen V Rouwet, A H Jan Danser, Jeroen Essers
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3153486?pdf=render

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