Photoinduced Synthesis of New Diisochromenochromen-4-ones and Their Antimicrobial Activities

Photoinduced Synthesis of New Diisochromenochromen-4-ones and Their Antimicrobial Activities

The diisochromenochromen-4-one 3a-3b, 4a-4c, 5a-6a  & 7 have been prepared from the photocyclization reaction of bischromen-4-one 2a-2e. The later compounds are obtained from the O-alkylation of the suitable 3-hydroxy-2-aryl-4H-chromen-4-one 1a-1e with 4,4′-bischloromethyl-diphenyl in dry aceton...

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Main Authors: Mohamad Yusuf, Indu Solanki, Payal Jain
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:The Scientific World Journal
Online Access:http://dx.doi.org/10.1100/2012/954934
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spelling doaj-a6d2069ebac64ca5a511a8a28d7cfa9f2020-11-25T02:24:29ZengHindawi LimitedThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/954934954934Photoinduced Synthesis of New Diisochromenochromen-4-ones and Their Antimicrobial ActivitiesMohamad Yusuf0Indu Solanki1Payal Jain2Department of Chemistry, Punjabi University, Punjab, Patiala147002, IndiaDepartment of Chemistry, Punjabi University, Punjab, Patiala147002, IndiaDepartment of Chemistry, Punjabi University, Punjab, Patiala147002, IndiaThe diisochromenochromen-4-one 3a-3b, 4a-4c, 5a-6a  & 7 have been prepared from the photocyclization reaction of bischromen-4-one 2a-2e. The later compounds are obtained from the O-alkylation of the suitable 3-hydroxy-2-aryl-4H-chromen-4-one 1a-1e with 4,4′-bischloromethyl-diphenyl in dry acetone, anhydrous K2CO3, and PTC (Bu4N+I−) under refluxing conditions. The structures of compounds 2a-2e, 3a-3b, 4a-4c, 5a-6a  & 7 have been characterized from the rigorous analysis of their IR, 1H-NMR, 13C-NMR, ESI-Mass, and elemental analysis. The antibacterial and antifungal activities of the synthesized products were also evaluated against the Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Bacillus subtilis, and Aspergillus janus and Penicillium glabrum, respectively. Some of the tested compounds showed significant activity against the above-said microorganisms.http://dx.doi.org/10.1100/2012/954934
collection DOAJ
language English
format Article
sources DOAJ
author Mohamad Yusuf
Indu Solanki
Payal Jain
spellingShingle Mohamad Yusuf
Indu Solanki
Payal Jain
Photoinduced Synthesis of New Diisochromenochromen-4-ones and Their Antimicrobial Activities
The Scientific World Journal
author_facet Mohamad Yusuf
Indu Solanki
Payal Jain
author_sort Mohamad Yusuf
title Photoinduced Synthesis of New Diisochromenochromen-4-ones and Their Antimicrobial Activities
title_short Photoinduced Synthesis of New Diisochromenochromen-4-ones and Their Antimicrobial Activities
title_full Photoinduced Synthesis of New Diisochromenochromen-4-ones and Their Antimicrobial Activities
title_fullStr Photoinduced Synthesis of New Diisochromenochromen-4-ones and Their Antimicrobial Activities
title_full_unstemmed Photoinduced Synthesis of New Diisochromenochromen-4-ones and Their Antimicrobial Activities
title_sort photoinduced synthesis of new diisochromenochromen-4-ones and their antimicrobial activities
publisher Hindawi Limited
series The Scientific World Journal
issn 1537-744X
publishDate 2012-01-01
description The diisochromenochromen-4-one 3a-3b, 4a-4c, 5a-6a  & 7 have been prepared from the photocyclization reaction of bischromen-4-one 2a-2e. The later compounds are obtained from the O-alkylation of the suitable 3-hydroxy-2-aryl-4H-chromen-4-one 1a-1e with 4,4′-bischloromethyl-diphenyl in dry acetone, anhydrous K2CO3, and PTC (Bu4N+I−) under refluxing conditions. The structures of compounds 2a-2e, 3a-3b, 4a-4c, 5a-6a  & 7 have been characterized from the rigorous analysis of their IR, 1H-NMR, 13C-NMR, ESI-Mass, and elemental analysis. The antibacterial and antifungal activities of the synthesized products were also evaluated against the Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Bacillus subtilis, and Aspergillus janus and Penicillium glabrum, respectively. Some of the tested compounds showed significant activity against the above-said microorganisms.
url http://dx.doi.org/10.1100/2012/954934
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AT indusolanki photoinducedsynthesisofnewdiisochromenochromen4onesandtheirantimicrobialactivities
AT payaljain photoinducedsynthesisofnewdiisochromenochromen4onesandtheirantimicrobialactivities
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