Autophagy Proteins in Viral Exocytosis and Anti-Viral Immune Responses
Abstract: Autophagy-related (Atg) gene-encoded proteins were originally described for their crucial role in macroautophagy, a catabolic pathway for cytoplasmic constituent degradation in lysosomes. Recently it has become clear that modules of this machinery can also be used to influence endo- and ex...
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MDPI AG
2017-10-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/9/10/288 |
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doaj-a6ce54321be5421aa7263d782cc62e392020-11-25T00:54:41ZengMDPI AGViruses1999-49152017-10-0191028810.3390/v9100288v9100288Autophagy Proteins in Viral Exocytosis and Anti-Viral Immune ResponsesChristian Münz0Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, SwitzerlandAbstract: Autophagy-related (Atg) gene-encoded proteins were originally described for their crucial role in macroautophagy, a catabolic pathway for cytoplasmic constituent degradation in lysosomes. Recently it has become clear that modules of this machinery can also be used to influence endo- and exocytosis. This mini review discusses how these alternative Atg functions support virus replication and viral antigen presentation on major histocompatibility (MHC) class I and II molecules. A better understanding of the modular use of the macroautophagy machinery might enable us to manipulate these alternative functions of Atg proteins during anti-viral therapies and to attenuate virus-induced immune pathologies.https://www.mdpi.com/1999-4915/9/10/288Epstein Barr virusVarizella Zoster viruspolioviruscoxsackie B virusMHC class I moleculesMHC class II moleculesLAP (LC3 associated phagocytosis) |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Christian Münz |
| spellingShingle |
Christian Münz Autophagy Proteins in Viral Exocytosis and Anti-Viral Immune Responses Viruses Epstein Barr virus Varizella Zoster virus poliovirus coxsackie B virus MHC class I molecules MHC class II molecules LAP (LC3 associated phagocytosis) |
| author_facet |
Christian Münz |
| author_sort |
Christian Münz |
| title |
Autophagy Proteins in Viral Exocytosis and Anti-Viral Immune Responses |
| title_short |
Autophagy Proteins in Viral Exocytosis and Anti-Viral Immune Responses |
| title_full |
Autophagy Proteins in Viral Exocytosis and Anti-Viral Immune Responses |
| title_fullStr |
Autophagy Proteins in Viral Exocytosis and Anti-Viral Immune Responses |
| title_full_unstemmed |
Autophagy Proteins in Viral Exocytosis and Anti-Viral Immune Responses |
| title_sort |
autophagy proteins in viral exocytosis and anti-viral immune responses |
| publisher |
MDPI AG |
| series |
Viruses |
| issn |
1999-4915 |
| publishDate |
2017-10-01 |
| description |
Abstract: Autophagy-related (Atg) gene-encoded proteins were originally described for their crucial role in macroautophagy, a catabolic pathway for cytoplasmic constituent degradation in lysosomes. Recently it has become clear that modules of this machinery can also be used to influence endo- and exocytosis. This mini review discusses how these alternative Atg functions support virus replication and viral antigen presentation on major histocompatibility (MHC) class I and II molecules. A better understanding of the modular use of the macroautophagy machinery might enable us to manipulate these alternative functions of Atg proteins during anti-viral therapies and to attenuate virus-induced immune pathologies. |
| topic |
Epstein Barr virus Varizella Zoster virus poliovirus coxsackie B virus MHC class I molecules MHC class II molecules LAP (LC3 associated phagocytosis) |
| url |
https://www.mdpi.com/1999-4915/9/10/288 |
| work_keys_str_mv |
AT christianmunz autophagyproteinsinviralexocytosisandantiviralimmuneresponses |
| _version_ |
1725233317613142016 |