Autophagy Proteins in Viral Exocytosis and Anti-Viral Immune Responses

Abstract: Autophagy-related (Atg) gene-encoded proteins were originally described for their crucial role in macroautophagy, a catabolic pathway for cytoplasmic constituent degradation in lysosomes. Recently it has become clear that modules of this machinery can also be used to influence endo- and ex...

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Bibliographic Details
Main Author: Christian Münz
Format: Article
Language:English
Published: MDPI AG 2017-10-01
Series:Viruses
Subjects:
Online Access:https://www.mdpi.com/1999-4915/9/10/288
Description
Summary:Abstract: Autophagy-related (Atg) gene-encoded proteins were originally described for their crucial role in macroautophagy, a catabolic pathway for cytoplasmic constituent degradation in lysosomes. Recently it has become clear that modules of this machinery can also be used to influence endo- and exocytosis. This mini review discusses how these alternative Atg functions support virus replication and viral antigen presentation on major histocompatibility (MHC) class I and II molecules. A better understanding of the modular use of the macroautophagy machinery might enable us to manipulate these alternative functions of Atg proteins during anti-viral therapies and to attenuate virus-induced immune pathologies.
ISSN:1999-4915