Optimization algorithms for functional deimmunization of therapeutic proteins

<p>Abstract</p> <p>Background</p> <p>To develop protein therapeutics from exogenous sources, it is necessary to mitigate the risks of eliciting an anti-biotherapeutic immune response. A key aspect of the response is the recognition and surface display by antigen-present...

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Bibliographic Details
Main Authors: Griswold Karl E, Zheng Wei, Parker Andrew S, Bailey-Kellogg Chris
Format: Article
Language:English
Published: BMC 2010-04-01
Series:BMC Bioinformatics
Online Access:http://www.biomedcentral.com/1471-2105/11/180