Functional short tandem repeat polymorphism of PTPN11 and susceptibility to hepatocellular carcinoma in Chinese populations.

Functional short tandem repeat polymorphism of PTPN11 and susceptibility to hepatocellular carcinoma in Chinese populations.

BACKGROUND: PTPN11, which encodes tyrosine phosphatase Shp2, is a critical gene mediating cellular responses to hormones and cytokines. Loss of Shp2 promotes hepatocellular carcinoma (HCC), suggesting that PTPN11 functions as a tumor suppressor in HCC tumorgenesis. The aim of this study was to evalu...

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Bibliographic Details
Main Authors: Xiankun Zhao, Shuxiang Hu, Lu Wang, Qing Zhang, Xiaodan Zhu, Hua Zhao, Chaoqun Wang, Ruiyang Tao, Siping Guo, Jing Wang, Jiejie Xu, Yan He, Yuzhen Gao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4157842?pdf=render

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