Aβ initiates brain hypometabolism, network dysfunction and behavioral abnormalities via NOX2-induced oxidative stress in mice

Aβ initiates brain hypometabolism, network dysfunction and behavioral abnormalities via NOX2-induced oxidative stress in mice

Anton Malkov, Irina Popova et al. demonstrate that beta-amyloid application induces oxidative stress and reduces glucose consumption in the mouse brain, leading to network hyperactivity and behavioral changes—pathologies similar to those observed early on in Alzheimer’s disease patients. Inhibition...

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Bibliographic Details
Main Authors: Anton Malkov, Irina Popova, Anton Ivanov, Sung-Soo Jang, Seo Yeon Yoon, Alexander Osypov, Yadong Huang, Yuri Zilberter, Misha Zilberter
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02551-x

Internet

https://doi.org/10.1038/s42003-021-02551-x

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