Mendelian Randomization Study: The Association Between Metabolic Pathways and Colorectal Cancer Risk

Background: The roles of obesity-related biomarkers and their molecular pathways in the development of postmenopausal colorectal cancer (CRC) have been inconclusive. We examined insulin resistance (IR) as a major hormonal pathway mediating the association between obesity and CRC risk in a Mendelian...

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Bibliographic Details
Main Authors: Su Yon Jung, Jeanette C. Papp, Eric M. Sobel, Zuo-Feng Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Oncology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01005/full