Spontaneous Ovarian Hyperstimulation Syndrome with FSH Receptor Gene Mutation: Two Rare Case Reports

Spontaneous Ovarian Hyperstimulation Syndrome with FSH Receptor Gene Mutation: Two Rare Case Reports

Development of ovarian hyperstimulation syndrome (OHSS) is very rare in a spontaneous ovulatory cycle and it is usually seen during pregnancy. In the etiology of OHSS, higher hCG (molar pregnancies or multiple pregnancies) and thyroid-stimulating hormone (TSH) levels have been accused. In recent yea...

Full description

Bibliographic Details
Main Authors: Emsal Pinar Topdagi Yilmaz, Omer Erkan Yapca, Yunus Emre Topdagi, Seray Kaya Topdagi, Yakup Kumtepe
Format: Article
Language:English
Published: Hindawi Limited 2018-01-01
Series:Case Reports in Obstetrics and Gynecology
Online Access:http://dx.doi.org/10.1155/2018/9294650
id doaj-a6bf7ac0d0c74d66bbca882c7c8c0b40
record_format Article
spelling doaj-a6bf7ac0d0c74d66bbca882c7c8c0b402020-11-24T21:06:35ZengHindawi LimitedCase Reports in Obstetrics and Gynecology2090-66842090-66922018-01-01201810.1155/2018/92946509294650Spontaneous Ovarian Hyperstimulation Syndrome with FSH Receptor Gene Mutation: Two Rare Case ReportsEmsal Pinar Topdagi Yilmaz0Omer Erkan Yapca1Yunus Emre Topdagi2Seray Kaya Topdagi3Yakup Kumtepe4Department of Gynecology and Obstetrics, Atatürk University School of Medicine, Erzurum, TurkeyDepartment of Gynecology and Obstetrics, Atatürk University School of Medicine, Erzurum, TurkeyClinic of Gynecology and Obstetrics, Nenehatun Gynecology and Obstetrics Hospital, Erzurum, TurkeyDepartment of Gynecology and Obstetrics, Atatürk University School of Medicine, Erzurum, TurkeyDepartment of Gynecology and Obstetrics, Atatürk University School of Medicine, Erzurum, TurkeyDevelopment of ovarian hyperstimulation syndrome (OHSS) is very rare in a spontaneous ovulatory cycle and it is usually seen during pregnancy. In the etiology of OHSS, higher hCG (molar pregnancies or multiple pregnancies) and thyroid-stimulating hormone (TSH) levels have been accused. In recent years, some follicle-stimulating hormone (FSH) receptor (FSHR) gene mutations have been described in patients with OHSS in the first trimester with normal hCG levels. Herein, we report two cases of FSHR gene mutation during the investigation of the etiology of spontaneous OHSS. Although OHSS is typically associated with ovulation induction, it should be kept in mind that this condition may also develop in spontaneous pregnancies.http://dx.doi.org/10.1155/2018/9294650
collection DOAJ
language English
format Article
sources DOAJ
author Emsal Pinar Topdagi Yilmaz
Omer Erkan Yapca
Yunus Emre Topdagi
Seray Kaya Topdagi
Yakup Kumtepe
spellingShingle Emsal Pinar Topdagi Yilmaz
Omer Erkan Yapca
Yunus Emre Topdagi
Seray Kaya Topdagi
Yakup Kumtepe
Spontaneous Ovarian Hyperstimulation Syndrome with FSH Receptor Gene Mutation: Two Rare Case Reports
Case Reports in Obstetrics and Gynecology
author_facet Emsal Pinar Topdagi Yilmaz
Omer Erkan Yapca
Yunus Emre Topdagi
Seray Kaya Topdagi
Yakup Kumtepe
author_sort Emsal Pinar Topdagi Yilmaz
title Spontaneous Ovarian Hyperstimulation Syndrome with FSH Receptor Gene Mutation: Two Rare Case Reports
title_short Spontaneous Ovarian Hyperstimulation Syndrome with FSH Receptor Gene Mutation: Two Rare Case Reports
title_full Spontaneous Ovarian Hyperstimulation Syndrome with FSH Receptor Gene Mutation: Two Rare Case Reports
title_fullStr Spontaneous Ovarian Hyperstimulation Syndrome with FSH Receptor Gene Mutation: Two Rare Case Reports
title_full_unstemmed Spontaneous Ovarian Hyperstimulation Syndrome with FSH Receptor Gene Mutation: Two Rare Case Reports
title_sort spontaneous ovarian hyperstimulation syndrome with fsh receptor gene mutation: two rare case reports
publisher Hindawi Limited
series Case Reports in Obstetrics and Gynecology
issn 2090-6684
2090-6692
publishDate 2018-01-01
description Development of ovarian hyperstimulation syndrome (OHSS) is very rare in a spontaneous ovulatory cycle and it is usually seen during pregnancy. In the etiology of OHSS, higher hCG (molar pregnancies or multiple pregnancies) and thyroid-stimulating hormone (TSH) levels have been accused. In recent years, some follicle-stimulating hormone (FSH) receptor (FSHR) gene mutations have been described in patients with OHSS in the first trimester with normal hCG levels. Herein, we report two cases of FSHR gene mutation during the investigation of the etiology of spontaneous OHSS. Although OHSS is typically associated with ovulation induction, it should be kept in mind that this condition may also develop in spontaneous pregnancies.
url http://dx.doi.org/10.1155/2018/9294650
work_keys_str_mv AT emsalpinartopdagiyilmaz spontaneousovarianhyperstimulationsyndromewithfshreceptorgenemutationtworarecasereports
AT omererkanyapca spontaneousovarianhyperstimulationsyndromewithfshreceptorgenemutationtworarecasereports
AT yunusemretopdagi spontaneousovarianhyperstimulationsyndromewithfshreceptorgenemutationtworarecasereports
AT seraykayatopdagi spontaneousovarianhyperstimulationsyndromewithfshreceptorgenemutationtworarecasereports
AT yakupkumtepe spontaneousovarianhyperstimulationsyndromewithfshreceptorgenemutationtworarecasereports
_version_ 1716765284419764224

Similar Items